The Observational Study of Growth Hormone-secreting Pituitary Tumors

This study is currently recruiting participants. (see Contacts and Locations)
Verified September 2013 by Huashan Hospital
National Natural Science Foundation of China
Information provided by (Responsible Party):
Zhaoyun Zhang, Huashan Hospital Identifier:
First received: June 6, 2011
Last updated: September 24, 2013
Last verified: September 2013

The major purpose of this study is to evaluate the changes of multiple organs in patients with growth hormone-secreting pituitary tumors before and after surgery. Plasma, DNA samples and pituitary tumor tissues will be kept for further analysis.

Pituitary Tumor

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Observational Study of the Structures and Functions of Multiple Organs in Patients With Growth Hormone-secreting Tumors

Resource links provided by NLM:

Further study details as provided by Huashan Hospital:

Biospecimen Retention:   Samples With DNA

Plasma, DNA and pituitary tumor tissues

Estimated Enrollment: 60
Study Start Date: May 2011
Estimated Study Completion Date: December 2013
Estimated Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Detailed Description:

Multiple organs or systems will be affected by excessive growth hormones in patients with acromegaly. The major purpose of this study is to evaluate the changes before and after the pituitary surgery.


Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

The acromegaly patients at Huashan Hospital will be recruited anf followed up prior to surgery and one month, 3 months, 6 months and 12 months after surgery.


Inclusion Criteria:

  • Clinical diagnosis of acromegaly
  • > 18 years old
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01368133

Contact: Jiahui Qiu, M.D. 86-13585951850
Contact: zhaoyun zhang, M.D. 86-21-52888286

Huashan Hospital Recruiting
Shanghai, China, 200040
Contact: Cuiyun Wu    86-21-52888047   
Contact: Zhaoyun Zhang    86-21-52888286   
Principal Investigator: Yao Zhao, M.D.         
Sponsors and Collaborators
Huashan Hospital
National Natural Science Foundation of China
Principal Investigator: Yao Zhao, M.D. Huashan Hospital
  More Information

No publications provided

Responsible Party: Zhaoyun Zhang, Associate Professor, Huashan Hospital Identifier: NCT01368133     History of Changes
Other Study ID Numbers: 2010M-010
Study First Received: June 6, 2011
Last Updated: September 24, 2013
Health Authority: China: Food and Drug Administration

Keywords provided by Huashan Hospital:
pituitary tumor

Additional relevant MeSH terms:
Pituitary Neoplasms
Brain Diseases
Brain Neoplasms
Central Nervous System Diseases
Central Nervous System Neoplasms
Endocrine Gland Neoplasms
Endocrine System Diseases
Hypothalamic Diseases
Hypothalamic Neoplasms
Neoplasms by Site
Nervous System Diseases
Nervous System Neoplasms
Pituitary Diseases
Supratentorial Neoplasms processed this record on March 26, 2015