Assessment of Bone Micro-Architecture Using HR-pQCT
|ClinicalTrials.gov Identifier: NCT01367730|
Recruitment Status : Completed
First Posted : June 7, 2011
Last Update Posted : December 2, 2014
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||80 participants|
|Official Title:||Non-Invasive Assessment of Bone Micro-architecture and Strength Changes in Men With Osteopenia and Osteoporosis|
|Study Start Date :||April 2012|
|Actual Primary Completion Date :||June 2014|
|Actual Study Completion Date :||June 2014|
osteoporosis and osteopenia
Subjects will be stratified based on DXA BMD T-scores.
- Measure cross-sectional and longitudinal differences in bone micro-architecture and strength changes in men with BMD T-scores ≤-2.0 and those with T-scores >-1.0. [ Time Frame: 12 months ]Trabecular bone micro-architecture as measured by trabecular number, trabecular BMD, and trabecular bone volume fraction (BV/TV). Cortical bone micro-architecture will be assessed by measuring cortical density & thickness and porosity.
- Change in Compressive biomechanical bone properties from Baseline to 12 months [ Time Frame: 12 months ]Calculate the change in compressive biomechanical properties using µ-finite element analysis
- Association between BMD, bone micro-architecture, compressive biomechanical properties and body composition at all timepoints [ Time Frame: Baseline and 12 months ]Association between BMD, bone micro-architecture, compressive biomechanical properties and body composition at all timepoints using DXA, HR-pQCT, microfinite element analysis.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01367730
|United States, California|
|UCSF Imaging Center|
|San Francisco, California, United States, 94107|
|Principal Investigator:||Sharmila Majumdar, PhD||University of California, San Francisco|