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Gut Hormones After Meal Ingestion in Males Versus Females

This study has been completed.
Information provided by (Responsible Party):
Bo Ahren, Lund University Identifier:
First received: May 31, 2011
Last updated: September 29, 2014
Last verified: September 2014
The study hypothesis is that the release of gut hormones is increased proportionally to caloric load in each meal. Three different meals with different meal size will therefore be served and gut hormones determined.

Condition Intervention
Normal Non-fluency Other: Meal ingestion

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Factorial Assignment
Masking: Open Label
Official Title: Effects of Varying Meal Size on Gut Hormone and Islet Hormone Secretion in Males Versus Females

Resource links provided by NLM:

Further study details as provided by Bo Ahren, Lund University:

Primary Outcome Measures:
  • Release of gut hormones [ Time Frame: 300 min ]

Secondary Outcome Measures:
  • Insulin secretion [ Time Frame: 300 min ]

Enrollment: 24
Study Start Date: May 2011
Study Completion Date: June 2014
Primary Completion Date: February 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Healthy males
Meal ingestion in healthy males
Other: Meal ingestion
Meal 511 kcal, meal 743 kcal or meal 1034 kcal
Experimental: Healthy females
Meal ingestion in healthy females
Other: Meal ingestion
Meal 511 kcal, meal 743 kcal or meal 1034 kcal

Detailed Description:
In healthy males and females, meals with 511, 743 and 1034 kcal will be given orally. Samples will be taken during the following 300 min and gut hormones (glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1) will be determined along with insulin and glucagon levels.

Ages Eligible for Study:   20 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy status

Exclusion Criteria:

  • Diabetes
  • Liver disease
  • kidney disease
  • thyroid disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT01366781

Department of Clinical Sciences Lund, Lund University
Lund, Sweden, 221 84
Sponsors and Collaborators
Lund University
Principal Investigator: Bo Ahrén, PhD Lund University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Bo Ahren, Professor, Lund University Identifier: NCT01366781     History of Changes
Other Study ID Numbers: 004
Study First Received: May 31, 2011
Last Updated: September 29, 2014

Keywords provided by Bo Ahren, Lund University:
Gut hormones
Insulin secretion

Additional relevant MeSH terms:
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs processed this record on June 23, 2017