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Gut Hormones After Meal Ingestion in Males Versus Females

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01366781
First Posted: June 6, 2011
Last Update Posted: September 30, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Bo Ahren, Lund University
  Purpose
The study hypothesis is that the release of gut hormones is increased proportionally to caloric load in each meal. Three different meals with different meal size will therefore be served and gut hormones determined.

Condition Intervention
Normal Non-fluency Other: Meal ingestion

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)
Official Title: Effects of Varying Meal Size on Gut Hormone and Islet Hormone Secretion in Males Versus Females

Resource links provided by NLM:


Further study details as provided by Bo Ahren, Lund University:

Primary Outcome Measures:
  • Release of gut hormones [ Time Frame: 300 min ]

Secondary Outcome Measures:
  • Insulin secretion [ Time Frame: 300 min ]

Enrollment: 24
Study Start Date: May 2011
Study Completion Date: June 2014
Primary Completion Date: February 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Healthy males
Meal ingestion in healthy males
Other: Meal ingestion
Meal 511 kcal, meal 743 kcal or meal 1034 kcal
Experimental: Healthy females
Meal ingestion in healthy females
Other: Meal ingestion
Meal 511 kcal, meal 743 kcal or meal 1034 kcal

Detailed Description:
In healthy males and females, meals with 511, 743 and 1034 kcal will be given orally. Samples will be taken during the following 300 min and gut hormones (glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1) will be determined along with insulin and glucagon levels.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy status

Exclusion Criteria:

  • Diabetes
  • Liver disease
  • kidney disease
  • thyroid disease
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01366781


Locations
Sweden
Department of Clinical Sciences Lund, Lund University
Lund, Sweden, 221 84
Sponsors and Collaborators
Lund University
Investigators
Principal Investigator: Bo Ahrén, PhD Lund University
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Bo Ahren, Professor, Lund University
ClinicalTrials.gov Identifier: NCT01366781     History of Changes
Other Study ID Numbers: 004
First Submitted: May 31, 2011
First Posted: June 6, 2011
Last Update Posted: September 30, 2014
Last Verified: September 2014

Keywords provided by Bo Ahren, Lund University:
Gut hormones
Insulin secretion

Additional relevant MeSH terms:
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs