Gut Hormones After Meal Ingestion in Males Versus Females

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01366781
Recruitment Status : Completed
First Posted : June 6, 2011
Last Update Posted : September 30, 2014
Information provided by (Responsible Party):
Bo Ahren, Lund University

Brief Summary:
The study hypothesis is that the release of gut hormones is increased proportionally to caloric load in each meal. Three different meals with different meal size will therefore be served and gut hormones determined.

Condition or disease Intervention/treatment Phase
Normal Non-fluency Other: Meal ingestion Not Applicable

Detailed Description:
In healthy males and females, meals with 511, 743 and 1034 kcal will be given orally. Samples will be taken during the following 300 min and gut hormones (glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1) will be determined along with insulin and glucagon levels.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 24 participants
Allocation: Non-Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)
Official Title: Effects of Varying Meal Size on Gut Hormone and Islet Hormone Secretion in Males Versus Females
Study Start Date : May 2011
Actual Primary Completion Date : February 2014
Actual Study Completion Date : June 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Hormones
U.S. FDA Resources

Arm Intervention/treatment
Experimental: Healthy males
Meal ingestion in healthy males
Other: Meal ingestion
Meal 511 kcal, meal 743 kcal or meal 1034 kcal
Experimental: Healthy females
Meal ingestion in healthy females
Other: Meal ingestion
Meal 511 kcal, meal 743 kcal or meal 1034 kcal

Primary Outcome Measures :
  1. Release of gut hormones [ Time Frame: 300 min ]

Secondary Outcome Measures :
  1. Insulin secretion [ Time Frame: 300 min ]

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy status

Exclusion Criteria:

  • Diabetes
  • Liver disease
  • kidney disease
  • thyroid disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01366781

Department of Clinical Sciences Lund, Lund University
Lund, Sweden, 221 84
Sponsors and Collaborators
Lund University
Principal Investigator: Bo Ahrén, PhD Lund University

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Bo Ahren, Professor, Lund University Identifier: NCT01366781     History of Changes
Other Study ID Numbers: 004
First Posted: June 6, 2011    Key Record Dates
Last Update Posted: September 30, 2014
Last Verified: September 2014

Keywords provided by Bo Ahren, Lund University:
Gut hormones
Insulin secretion

Additional relevant MeSH terms:
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs