Biomarker in Tissue Samples From Patients With Ewing Sarcoma

This study is ongoing, but not recruiting participants.
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group Identifier:
First received: June 1, 2011
Last updated: September 30, 2015
Last verified: May 2015

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies biomarkers in tissue samples from patients with Ewing sarcoma.

Condition Intervention
Genetic: microarray analysis
Genetic: protein analysis
Other: immunohistochemistry staining method
Other: laboratory biomarker analysis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: INI-1 Deletions in Ewing Sarcoma

Resource links provided by NLM:

Further study details as provided by Children's Oncology Group:

Primary Outcome Measures:
  • Frequency of INI1 protein loss in Ewing Sarcoma [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA


Estimated Enrollment: 40
Study Start Date: May 2011
Estimated Primary Completion Date: January 2100 (Final data collection date for primary outcome measure)
Detailed Description:


  • To determine the frequency of INI-1 protein loss in Ewing Sarcoma.

OUTLINE: Previously collected tissue samples are analyzed for INI-1 protein loss by IHC and tissue microarray.


Ages Eligible for Study:   up to 120 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Diagnosis of Ewing sarcoma.



  • Diagnosis of Ewing sarcoma
  • Prepared tissue microarray with Ewing sarcoma samples available


  • Not specified


  • Not specified
  Contacts and Locations
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Please refer to this study by its identifier: NCT01365949

Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Joshua D. Schiffman, MD University of Utah
  More Information

Additional Information:
No publications provided

Responsible Party: Children's Oncology Group Identifier: NCT01365949     History of Changes
Other Study ID Numbers: AEWS11B1, COG-AEWS11B1, NCI-2011-02857, AEWS11B1
Study First Received: June 1, 2011
Last Updated: September 30, 2015
Health Authority: United States: Federal Government

Keywords provided by Children's Oncology Group:
Ewing sarcoma/peripheral primitive neuroectodermal tumor (PNET)

Additional relevant MeSH terms:
Sarcoma, Ewing
Neoplasms by Histologic Type
Neoplasms, Bone Tissue
Neoplasms, Connective Tissue
Neoplasms, Connective and Soft Tissue
Osteosarcoma processed this record on October 07, 2015