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Biomarker in Tissue Samples From Patients With Ewing Sarcoma

This study has been completed.
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group Identifier:
First received: June 1, 2011
Last updated: July 7, 2016
Last verified: July 2016

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies biomarkers in tissue samples from patients with Ewing sarcoma.

Condition Intervention
Genetic: microarray analysis
Genetic: protein analysis
Other: immunohistochemistry staining method
Other: laboratory biomarker analysis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: INI-1 Deletions in Ewing Sarcoma

Resource links provided by NLM:

Further study details as provided by Children's Oncology Group:

Primary Outcome Measures:
  • Frequency of INI1 protein loss in Ewing Sarcoma

Biospecimen Retention:   Samples With DNA

Estimated Enrollment: 40
Study Start Date: May 2011
Primary Completion Date: July 2016 (Final data collection date for primary outcome measure)
Detailed Description:


  • To determine the frequency of INI-1 protein loss in Ewing Sarcoma.

OUTLINE: Previously collected tissue samples are analyzed for INI-1 protein loss by IHC and tissue microarray.


Ages Eligible for Study:   up to 120 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Diagnosis of Ewing sarcoma.


  • Diagnosis of Ewing sarcoma
  • Prepared tissue microarray with Ewing sarcoma samples available


  • Not specified


  • Not specified
  Contacts and Locations
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Please refer to this study by its identifier: NCT01365949

Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Joshua D. Schiffman, MD University of Utah
  More Information

Responsible Party: Children's Oncology Group Identifier: NCT01365949     History of Changes
Other Study ID Numbers: AEWS11B1
COG-AEWS11B1 ( Other Identifier: Children's Oncology Group )
NCI-2011-02857 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
AEWS11B1 ( Other Identifier: Children's Oncology Group )
Study First Received: June 1, 2011
Last Updated: July 7, 2016

Keywords provided by Children's Oncology Group:
Ewing sarcoma/peripheral primitive neuroectodermal tumor (PNET)

Additional relevant MeSH terms:
Sarcoma, Ewing
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Neoplasms, Bone Tissue
Neoplasms, Connective Tissue processed this record on April 28, 2017