Biomarker in Tissue Samples From Patients With Ewing Sarcoma

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01365949
Recruitment Status : Completed
First Posted : June 3, 2011
Last Update Posted : July 11, 2016
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group

Brief Summary:

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies biomarkers in tissue samples from patients with Ewing sarcoma.

Condition or disease Intervention/treatment
Sarcoma Genetic: microarray analysis Genetic: protein analysis Other: immunohistochemistry staining method Other: laboratory biomarker analysis

Detailed Description:


  • To determine the frequency of INI-1 protein loss in Ewing Sarcoma.

OUTLINE: Previously collected tissue samples are analyzed for INI-1 protein loss by IHC and tissue microarray.

Study Type : Observational
Estimated Enrollment : 40 participants
Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: INI-1 Deletions in Ewing Sarcoma
Study Start Date : May 2011
Actual Primary Completion Date : July 2016

Primary Outcome Measures :
  1. Frequency of INI1 protein loss in Ewing Sarcoma

Biospecimen Retention:   Samples With DNA

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 120 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Diagnosis of Ewing sarcoma.


  • Diagnosis of Ewing sarcoma
  • Prepared tissue microarray with Ewing sarcoma samples available


  • Not specified


  • Not specified

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01365949

Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Joshua D. Schiffman, MD University of Utah

Responsible Party: Children's Oncology Group Identifier: NCT01365949     History of Changes
Other Study ID Numbers: AEWS11B1
COG-AEWS11B1 ( Other Identifier: Children's Oncology Group )
NCI-2011-02857 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
AEWS11B1 ( Other Identifier: Children's Oncology Group )
First Posted: June 3, 2011    Key Record Dates
Last Update Posted: July 11, 2016
Last Verified: July 2016

Keywords provided by Children's Oncology Group:
Ewing sarcoma/peripheral primitive neuroectodermal tumor (PNET)

Additional relevant MeSH terms:
Sarcoma, Ewing
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Neoplasms, Bone Tissue
Neoplasms, Connective Tissue