CYCORE: Cyberinfrastructure for Comparative Effectiveness Research - Feasibility Trial

Inclusion Criteria:

1. Diagnosis of any stage I - IV colorectal cancer or recurrent colorectal cancer (Arm 1)
2. Able to speak, read, and write in English (Pre-pilot phase, Arms 1-4)
3. Able to provide informed consent (Pre-pilot phase, Arms 1-4, PCS study)
4. Lives in the Houston area (Harris county or a contiguous county) (Pre-pilot phase)
5. Age 18 years or older (Pre-pilot phase, Arms 1-4)
6. ECOG status of 0 - 2, or self reports being up and about more than 50% of waking hours and able to provide self care (Arm 1)
7. Diagnosis of any of the following cancers: stage 1-4b oropharyngeal, hypopharyngeal, nasopharyngeal, salivary gland or oral cavity; stage 3-4b laryngeal; any unknown primary head and neck cancer with cervical metastasis that will be addressed with treatment to bilateral necks and mucosa; or other head and neck cancers medically approved by one of our Radiation Oncology collaborating MDs (Arms 2 and 3)
8. History of any cancer, other than non-melanoma skin cancer (Arm 4)
9. Admitted to being a current smoker or recent quitter upon admission to MDACC (Arm 4)
10. Has a valid home address and functioning home telephone number (Arm 4)
11. Lives in the Houston or surrounding area, or resides in this same area during the time period that coincides with this study (Arms 1-4)
12. Patients who will undergo curative pancreatectomy for pancreatic adenocarcinoma, pancreatic neuroendocrine tumors, or pancreatic cysts (malignant or benign) (PCS study)
13. Fluent in English (PCS study)
14. Must have telephone access and agree to engage with research personnel using telephone (PCS study)

Exclusion Criteria:

1. Major surgery in the past 8 weeks (Arms 1 and 4)
2. Self-reports hypertension that is not being monitored by a physician and is not being managed with either medication, observation, or lifestyle change (Pre-pilot phase, Arms 1-3)
3. Overt cognitive difficulty demonstrated by not being clearly oriented to time or person or place (Arms 1-4)
4. Orthopedic, neurologic, or musculoskeletal disability that would interfere with the functional task of standing on a weight scale (Pre-pilot phase, Arm 2)
5. Not currently receiving radiation treatment for a cancer listed in the Arm-specific inclusion criteria (Arms 2 and 3)
6. Zubrod Performance Status >2, or self reports either not being up and about more than 50% of waking hours or unable to provide self care (Arms 2 and 3)
7. Currently receiving treatment for a cancer other than those listed in the Arm-specific inclusion criteria (exception: the study does not exclude those receiving treatment for non-melanoma skin cancer) (Arms 2 and 3)
8. History of current oropharyngeal dysphagia unrelated to cancer diagnosis (e.g. dysphagia due to underlying neurogenic disorder) (Arm 3 only)
9. Active substance use disorder (diagnosed or strongly suspected) (Arm 4)
10. Currently enrolled in protocol 2014-0712 (PCS study)
11. No home access to internet (PCS study)
12. No home WiFi connection (PCS study)
13. During clinician's pre-surgical evaluation, presents with high risk for non-therapeutic resection related to cancer diagnosis (PCS study)
14. Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease (New York Heart Association functional class III or IV) (PCS study)
15. Recent fracture or acute musculoskeletal injury that precludes the ability to fully bear weight on all 4 limbs in order to participate in an exercise intervention (PCS study)
16. Poorly-controlled pain with a self-reported pain score of ≥ 7/10 at the time of enrollment (PCS study)
17. Myopathic or rheumatologic disease that impacts physical function (PCS study)
18. Has a pacemaker or other internal medical device, or reports being pregnant (PCS study)