31P-MRS and Huntington Disease (PRO-MH)
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|ClinicalTrials.gov Identifier: NCT01359774|
Recruitment Status : Completed
First Posted : May 25, 2011
Last Update Posted : September 21, 2012
|Condition or disease||Intervention/treatment||Phase|
|Huntington Disease||Other: 31P-MR spectroscopy Other: 31P-RMN spectroscopy||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||30 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||31Phosphorus-Magnetic Resonance Spectroscopy and Huntington Disease|
|Study Start Date :||April 2011|
|Actual Primary Completion Date :||April 2012|
|Actual Study Completion Date :||April 2012|
Other: 31P-MR spectroscopy
Brain energy deficit is quantified using 31P-MR spectroscopy
Other: 31P-RMN spectroscopy
Brain energy deficit is quantified using 31P-RMN spectroscopy
- Brain energy deficit in Huntington patients [ Time Frame: one year ]
31P-MRS allows quantification of high-energy phosphate metabolites such as ATP and phosphocreatine.
Objective: to look at brain energy metabolism during rest and activation.
- Correlating a brain energy deficit with (i) biochemical parameters and (ii) clinical parameters in Huntington patients [ Time Frame: one year ]
Biochemical parameters include metabolites that we previously showed to be biomarkers in HD: branched chain amino acids and IGF1.
Clinical parameters include UHDRS and TFC.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01359774
|Hopital de la Pitié-Salpetrière|
|Paris, France, 75013|
|Principal Investigator:||Fanny Mochel, MD, PhD||INSERM UMR S975 Institut du Cerveau et de la Moelle, AP-HP Département de Génétique, Université Pierre et Marie Curie, Paris France|