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Clinical Study of Novel Diagnostic Techniques for Knee Osteoarthritis

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01359553
First Posted: May 24, 2011
Last Update Posted: October 26, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Oulu University Hospital
University of Eastern Finland
Kuopio University Hospital
Information provided by (Responsible Party):
Simo Saarakkala, University of Oulu
  Purpose
The purpose of this study is to clarify the potential of intra-articular ultrasound imaging, non-invasive ultrasound imaging, quantitative MRI imaging, contrast-enhanced CT imaging and arthroscopy for diagnostics of knee osteoarthritis. All methods will be cross-correlated and compared with the arthroscopic findings.

Condition Intervention
Knee Osteoarthritis Knee Injuries Other: Intra-articular ultrasound imaging of knee joint during arthroscopy Other: Non-invasive ultrasound imaging of knee Other: Quantitative MRI imaging of knee Other: Contrast-enhanced CT imaging of knee

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Comparison Between Intra-articular Ultrasound Imaging, Non-invasive Ultrasound Imaging, Quantitative MRI Imaging, Contrast-enhanced CT Imaging and Arthroscopy for Diagnostics of Knee Osteoarthritis

Resource links provided by NLM:


Further study details as provided by Simo Saarakkala, University of Oulu:

Primary Outcome Measures:
  • Arthroscopical OA grade [ Time Frame: 2014 ]

Enrollment: 12
Study Start Date: May 2011
Study Completion Date: May 2014
Primary Completion Date: April 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Knee pain
Group with knee pain problems referred to an arthroscopy.
Other: Intra-articular ultrasound imaging of knee joint during arthroscopy Other: Non-invasive ultrasound imaging of knee Other: Quantitative MRI imaging of knee Other: Contrast-enhanced CT imaging of knee

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients will be selected from those referred to an arthroscopy because of pain symptoms in the knee.
Criteria

Inclusion Criteria:

  • Kellgren-Lawrence grade = 1-3 or cartilage defect detected in MRI
  • Age >= 20 years

Exclusion Criteria:

  • Tumor or inflammation in the knee
  • Severe general diseases
  • Diabetes
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01359553


Locations
Finland
Oulu University Hospital
Oulu, Finland, FI-90029
Sponsors and Collaborators
University of Oulu
Oulu University Hospital
University of Eastern Finland
Kuopio University Hospital
Investigators
Principal Investigator: Simo Saarakkala, Ph.D. University of Oulu and Oulu University Hospital
Study Director: Petri Lehenkari, M.D., Ph.D. University of Oulu and Oulu University Hospital
Study Director: Miika T Nieminen, Ph.D. University of Oulu and Oulu University Hospital
Study Director: Risto Ojala, M.D., Ph.D. Oulu University Hospital
  More Information

Responsible Party: Simo Saarakkala, Associate Professor, University of Oulu
ClinicalTrials.gov Identifier: NCT01359553     History of Changes
Other Study ID Numbers: UltraRusto
First Submitted: May 22, 2011
First Posted: May 24, 2011
Last Update Posted: October 26, 2016
Last Verified: October 2016

Additional relevant MeSH terms:
Osteoarthritis
Osteoarthritis, Knee
Knee Injuries
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Leg Injuries
Wounds and Injuries