Study of Methicillin-resistant Staphylococcus Aureus (MRSA) Isolated From Infected Patients in Brazil (MRSABrazil)
Recruitment status was: Not yet recruiting
This project has as general objective to determine if there is any Methicillin-resistant Staphylococcus aureus (MRSA) strain disseminating in the hospital of Belo Horizonte. If this is the case, the investigators will determine if this is an international known strain by typing it by PFGE and MLST.
The detection of mecA gene will be performed by PCR. Their susceptibility profile to several drugs will also be accessed and it will be possible to compare the response to those drugs commonly in use to that of Daptomycin, a new drug available in Brazil.
It will be screened for reduced susceptibility to vancomycin by Macromethod Etest (MET) in order to search for VISA or hetero-VISA. Also, due to the discussions at the literature about mutations in genes that are said to be responsible for reduced susceptibility to vancomycin, the investigators will sequence these genes in all PFGE type strain of this study looking for mutations already described to compare to the screening results.
Methicillin Resistant Staphylococcus Aureus
|Study Design:||Time Perspective: Retrospective|
|Official Title:||Epidemiological Study of Methicillin-resistant Staphylococcus Aureus (MRSA) Isolated From Infected Patients During a Hospital Surveillance Period|
|Study Start Date:||July 2011|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01359358
|Instituto de Física de Sao Carlos - Universidade de Sao Paulo|
|Sao Carlos, Sao Paulo, Brazil, 13560-590|
|Principal Investigator:||Ilana L B Camargo, PhD||University of Sao Paulo|