Right Ventricular Damage in Cardiovascular Magnetic Resonance

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01359306
Recruitment Status : Completed
First Posted : May 24, 2011
Last Update Posted : May 24, 2011
Information provided by:
University of Leipzig

Brief Summary:

The purpose of this study is to determine the predictors of right ventricular damage (RVD) assessed by wall motion abnormalities, edema, myocardial salvage and delayed enhancement (DE)cardiac magnetic resonance imaging in acute ST-elevation myocardial infarction (STEMI) and its prognostic significance.

The investigators hypothesize that ischemia related changes of the myocardium are also visible in the right ventricle and that they have an impact on patient outcome.

Condition or disease
Acute Myocardial Infarction

Study Type : Observational
Actual Enrollment : 524 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Right Ventricular Damage in ST-Elevation Myocardial Infarction. Risk Stratification by Visualization of Wall Motion, Edema and Delayed Enhancement Cardiovascular Magnetic Resonance
Study Start Date : February 2006
Primary Completion Date : May 2008
Study Completion Date : May 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Attack
U.S. FDA Resources

Primary Outcome Measures :
  1. Major Adverse Cardiac Event [ Time Frame: 30 months ]

Biospecimen Retention:   Samples Without DNA
serum for assessment of creatine kinase myocardial band

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
524 consecutive patients with ST elevation myocardial infarction.

Inclusion Criteria:

  • Onset of symptoms <12 h before angioplasty.
  • ST-segment elevation of at least 0.1 mV in ≥2 extremity leads or at least 0.2 mV in ≥2 precordial leads.

Exclusion Criteria:

  • Contraindications to CMR as implanted defibrillators, pacemakers, ferromagnetic intracranial metallic implants or pulmonary metallic splints and claustrophobia. A further exclusion criterion was prior fibrinolysis.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01359306

Sponsors and Collaborators
University of Leipzig
Principal Investigator: Matthias Grothoff, MD Heartcenter Leipzig GmbH

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Matthias Grothoff MD, University Leipzig Heart Center Identifier: NCT01359306     History of Changes
Other Study ID Numbers: RV-Damage 1/2007
First Posted: May 24, 2011    Key Record Dates
Last Update Posted: May 24, 2011
Last Verified: May 2011

Keywords provided by University of Leipzig:
Acute myocardial infarction
Right ventricular infarction
Cardiovascular Magnetic Resonance

Additional relevant MeSH terms:
Myocardial Infarction
ST Elevation Myocardial Infarction
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases