MI Mortality Risk and Between-hospital Risk Variation in the United Kingdom and Sweden
Acute Myocardial Infarction
|Study Design:||Observational Model: Cohort
Time Perspective: Retrospective
|Official Title:||Compare the Patient Risk and Between-hospital Variation in Myocardial Infarction Mortality in the United Kingdom and Sweden|
- 30-day mortality [ Time Frame: 30-day ]all-cause mortality at 30-day following hospitalization for acute Myocardial Infarction
- 1-year mortality [ Time Frame: 1 year ]all-cause mortality at 1-year following hospitalization for acute Myocardial Infarction
|Study Start Date:||March 2011|
|Estimated Study Completion Date:||December 2020|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
The Myocardial Ischaemia National Audit Project (MINAP) was established in 1999, in response to the national service framework (NSF) for coronary heart disease, to examine the quality of management of heart attacks (myocardial infarction) in hospitals in England and Wales.
The Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA) has been established to record clinical and treatment information for all patients admitted to the coronary care units in Sweden from 1995.
Limited evidence is available in comparing hospital level care and reference mortality risks between countries, due to the scarce availability of nationwide coronary heart disease data. The demographics and medical expenditure percentage are comparable in the United Kingdom and Sweden; however, the in-hospital case-fatality rates within 30 days after admission for acute myocardial infarction was greater in the UK than Sweden (6.3% versus 2.9%)(OECD, 2009). To investigate the discrepancy, the current study aims to compare the mortality risk differences and associated explanatory factors between the two countries. Results of the study can contribute to myocardial infarction care implementation in the UK and Sweden.
The UK Myocardial Ischaemia National Audit Project (MINAP)and Register of Information and Knowledge about Swedish Heart Intensive care Admissions (RIKS-HIA) are few quality national registries currently available for acute coronary syndrome. Using data from the MINAP and RIKS-HIA, we propose to investigate (1)the survival trajectories for a reference patient with myocardial infarction and (2) hospital variability in myocardial infarction mortality rate in the UK and Sweden, adjusted for important patient-level and hospital-level covariates.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01359033
|Uppsala Clinial Research Center|
|Uppsala, Sweden, SE-751 85|
|University College London|
|London, United Kingdom|
|Principal Investigator:||Sheng-Chia Chung, Ph.D||University College, London|