MI Mortality Risk and Between-hospital Risk Variation in the United Kingdom and Sweden
|ClinicalTrials.gov Identifier: NCT01359033|
Recruitment Status : Completed
First Posted : May 24, 2011
Last Update Posted : November 17, 2017
|Condition or disease|
|Acute Myocardial Infarction|
Limited evidence is available in comparing hospital level care and reference mortality risks between countries, due to the scarce availability of nationwide coronary heart disease data. The demographics and medical expenditure percentage are comparable in the United Kingdom and Sweden; however, the in-hospital case-fatality rates within 30 days after admission for acute myocardial infarction was greater in the UK than Sweden (6.3% versus 2.9%)(OECD, 2009). To investigate the discrepancy, the current study aims to compare the mortality risk differences and associated explanatory factors between the two countries. Results of the study can contribute to myocardial infarction care implementation in the UK and Sweden.
The UK Myocardial Ischaemia National Audit Project (MINAP)and Register of Information and Knowledge about Swedish Heart Intensive care Admissions (RIKS-HIA) are few quality national registries currently available for acute coronary syndrome. Using data from the MINAP and RIKS-HIA, we propose to investigate (1)the survival trajectories for a reference patient with myocardial infarction and (2) hospital variability in myocardial infarction mortality rate in the UK and Sweden, adjusted for important patient-level and hospital-level covariates.
|Study Type :||Observational|
|Actual Enrollment :||510863 participants|
|Official Title:||Compare the Patient Risk and Between-hospital Variation in Myocardial Infarction Mortality in the United Kingdom and Sweden|
|Study Start Date :||March 2011|
|Actual Primary Completion Date :||December 2013|
|Actual Study Completion Date :||December 2014|
The Myocardial Ischaemia National Audit Project (MINAP) was established in 1999, in response to the national service framework (NSF) for coronary heart disease, to examine the quality of management of heart attacks (myocardial infarction) in hospitals in England and Wales.
The Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA) has been established to record clinical and treatment information for all patients admitted to the coronary care units in Sweden from 1995.
- 30-day mortality [ Time Frame: 30-day ]all-cause mortality at 30-day following hospitalization for acute Myocardial Infarction
- 1-year mortality [ Time Frame: 1 year ]all-cause mortality at 1-year following hospitalization for acute Myocardial Infarction
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01359033
|Uppsala Clinial Research Center|
|Uppsala, Sweden, SE-751 85|
|University College London|
|London, United Kingdom|
|Principal Investigator:||Sheng-Chia Chung, Ph.D||University College, London|