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Metformin Treatment, Renal Function and Lactic Acidosis

This study has been completed.
Information provided by:
Skane University Hospital Identifier:
First received: May 19, 2011
Last updated: May 20, 2011
Last verified: April 2011
From a central registry at the National Board of Health and Welfare in Sweden collect all patients in the city of Malmö prescribed metformin during two years. Glomerular filtration rate (eGFR) was estimated from the CKD-EPI formula (n=5408) and compared to a control material (n=2815) from the same town. All cases of severe lactic acidosis rendering ICU admission were also sought. The study hypothesis is that metformin is prescribed to patients with lower GFR than anticipated with very few cases of lactic acidosis registered.

Type 2 Diabetes Mellitus

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Metformin Treatment, Renal Function and Lactic Acidosis. A Population Based

Resource links provided by NLM:

Further study details as provided by Skane University Hospital:

Enrollment: 4500
Study Start Date: January 2011
Study Completion Date: April 2011
Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All patients irrespective of age prescribed metformin according to a registry for the city of Malmö

Inclusion Criteria:

  • Patients in the city of Malmö prescribed metformin at least three times during two years
  • Available at least one p-creatinine during the two years

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT01358994

Dept of Nephrology
Malmö, Sweden, SE 20502
Sponsors and Collaborators
Skane University Hospital
  More Information

Responsible Party: Gunnar Sterner, Dept of Nephrology, Skane University Hospital Identifier: NCT01358994     History of Changes
Other Study ID Numbers: Metformin02
Study First Received: May 19, 2011
Last Updated: May 20, 2011

Keywords provided by Skane University Hospital:
type 2 diabetes
lactic acidosis

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Acidosis, Lactic
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Acid-Base Imbalance
Hypoglycemic Agents
Physiological Effects of Drugs processed this record on April 28, 2017