Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2010 by University of Oslo.
Recruitment status was  Recruiting
Oslo University Hospital
Information provided by:
University of Oslo Identifier:
First received: May 19, 2011
Last updated: May 23, 2011
Last verified: November 2010
The purpose of this study is to analyze genetic polymorphisms in genes encoding pro-inflammatory cytokines, and study the genetic predisposition to chronic periodontitis (CP) in combination with atherosclerotic cardiovascular (ACD) and aneurysmal diseases. The investigators will also try to identify oral bacteria in atherosclerotic plaques and aneurysmal walls and thrombus. Histological analyses of atherosclerotic plaques and aneurysmal wall will be performed.

Vascular Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Periodontal-, Cardiovascular- and Aneurysmal Diseases.

Resource links provided by NLM:

Further study details as provided by University of Oslo:

Biospecimen Retention:   Samples With DNA
Whole blood, samples from vascular tissues (atherosclerotic plaques and aneurysmal wall), saliva

Estimated Enrollment: 100
Study Start Date: October 2008
Estimated Study Completion Date: October 2015
Primary Completion Date: March 2011 (Final data collection date for primary outcome measure)

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis, and randomly selected blood donors at Oslo University Hospital, Ullevål.

Inclusion Criteria:

  • Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis,

Exclusion Criteria:

  • patients whom undergone antibiotic treatment the past month.
  • patients whom undergone periodontal treatment the past 6 months.
  • patients with no teeth
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01358630

Contact: Ingar Olsen, Prof.PhD. +47-22840350
Contact: Jørgen J Jørgensen, Prof.PhD +47-22894496

Dental and Medical Faculty, University of Oslo Recruiting
Oslo, Norway, 0316
Contact: Ingar Olsen, Prof.PhD    47 22 84 03 50   
Contact: Jørgensen J Jørgensen, Prof.PhD    47 22 89 44 96   
Sponsors and Collaborators
University of Oslo
Oslo University Hospital
  More Information

No publications provided

Responsible Party: Professor, Ph.D., Dr.Odont Ingar Olsen/Professor PhD.MD. Jørgen J. Jørgensen, Institute of Oral Biology, Dental Faculty, University of Oslo/Oslo University Hospital, Departemnt of vascular surgery Identifier: NCT01358630     History of Changes
Other Study ID Numbers: 08/322b
Study First Received: May 19, 2011
Last Updated: May 23, 2011
Health Authority: Norway: Regional Ethics Commitee

Keywords provided by University of Oslo:
Vascular disease
Proinflammatory cytokines

Additional relevant MeSH terms:
Vascular Diseases
Cardiovascular Diseases
Mouth Diseases
Periodontal Diseases
Stomatognathic Diseases processed this record on November 30, 2015