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Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2010 by University of Oslo.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01358630
First Posted: May 24, 2011
Last Update Posted: May 24, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Oslo University Hospital
Information provided by:
University of Oslo
  Purpose
The purpose of this study is to analyze genetic polymorphisms in genes encoding pro-inflammatory cytokines, and study the genetic predisposition to chronic periodontitis (CP) in combination with atherosclerotic cardiovascular (ACD) and aneurysmal diseases. The investigators will also try to identify oral bacteria in atherosclerotic plaques and aneurysmal walls and thrombus. Histological analyses of atherosclerotic plaques and aneurysmal wall will be performed.

Condition
Periodontitis Vascular Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Periodontal-, Cardiovascular- and Aneurysmal Diseases.

Further study details as provided by University of Oslo:

Biospecimen Retention:   Samples With DNA
Whole blood, samples from vascular tissues (atherosclerotic plaques and aneurysmal wall), saliva

Estimated Enrollment: 100
Study Start Date: October 2008
Estimated Study Completion Date: October 2015
Primary Completion Date: March 2011 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis, and randomly selected blood donors at Oslo University Hospital, Ullevål.
Criteria

Inclusion Criteria:

  • Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis,

Exclusion Criteria:

  • patients whom undergone antibiotic treatment the past month.
  • patients whom undergone periodontal treatment the past 6 months.
  • patients with no teeth
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01358630


Contacts
Contact: Ingar Olsen, Prof.PhD. +47-22840350 ingar.olsen@odont.uio.no
Contact: Jørgen J Jørgensen, Prof.PhD +47-22894496 j.j.jorgensen@medisin.uio.no

Locations
Norway
Dental and Medical Faculty, University of Oslo Recruiting
Oslo, Norway, 0316
Contact: Ingar Olsen, Prof.PhD    47 22 84 03 50    ingaro@odont.uio.no   
Contact: Jørgensen J Jørgensen, Prof.PhD    47 22 89 44 96    j.j.jorgensen@medisin.uio.no   
Sponsors and Collaborators
University of Oslo
Oslo University Hospital
  More Information

Responsible Party: Professor, Ph.D., Dr.Odont Ingar Olsen/Professor PhD.MD. Jørgen J. Jørgensen, Institute of Oral Biology, Dental Faculty, University of Oslo/Oslo University Hospital, Departemnt of vascular surgery
ClinicalTrials.gov Identifier: NCT01358630     History of Changes
Other Study ID Numbers: 08/322b
First Submitted: May 19, 2011
First Posted: May 24, 2011
Last Update Posted: May 24, 2011
Last Verified: November 2010

Keywords provided by University of Oslo:
Periodontitis
Vascular disease
Proinflammatory cytokines

Additional relevant MeSH terms:
Periodontitis
Vascular Diseases
Periodontal Diseases
Mouth Diseases
Stomatognathic Diseases
Cardiovascular Diseases