Prognostic Biomarkers in Tumor Tissue Samples From Young Patients With Neuroblastoma
Recruitment status was Active, not recruiting
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify biomarkers and learn more about biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in tumor tissue samples from young patients with neuroblastoma.
Genetic: microarray analysis
Genetic: protein expression analysis
Other: immunoenzyme technique
Other: laboratory biomarker analysis
|Official Title:||Expression of Ubiquitin Carboxyl-Terminal Hydrolase 1 (UCHL1) in Neuroblastoma Cancer Stem Cells and Its Relationship to Patient Prognosis|
- UCHL1 as an indirect marker of cancer stem cells [ Designated as safety issue: No ]
- UCHL1 as a biomarker of neuroblastoma prognosis [ Designated as safety issue: No ]
|Study Start Date:||May 2011|
|Estimated Primary Completion Date:||August 2011 (Final data collection date for primary outcome measure)|
- Determine whether ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) expression is an indirect cancer stem cell marker in pediatric patients with neuroblastoma.
- Correlate UCHL1 expression with staging information and patient's outcome.
OUTLINE: Archived tissue microarray samples are analyzed for ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) expression by UCHL1 monoclonal antibody and peroxidase technique. Results are then compared with patients' clinical data, including age at diagnosis, race, date of diagnosis, histology, stage and location at diagnosis, presence of cancer predisposition, date of completion of treatment, surgery performed, type of chemotherapy received, history of recurrence, and status (alive with disease, alive without disease, dead), if available.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01358617
|Principal Investigator:||Aaron Sugalski, MD||The University of Texas Health Science Center at San Antonio|