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Transcranial Direct Current Stimulation for Migraine Attack

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01358279
Recruitment Status : Completed
First Posted : May 23, 2011
Last Update Posted : October 25, 2016
Information provided by (Responsible Party):
Manho Kim, Seoul National University Hospital

Brief Summary:
This study is conducted to investigate the therapeutic efficacy and safety of transcranial direct current stimulation (tDCS) over the primary motor cortex of patients with acute migraine attack.

Condition or disease Intervention/treatment Phase
Acute Migraine Procedure: transcranial direct current stimulation Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 32 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Manho Kim, MD, PhD Professor, Neurology Seoul National University Hospital,
Study Start Date : January 2009
Actual Primary Completion Date : October 2009
Actual Study Completion Date : March 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Migraine

Arm Intervention/treatment
Experimental: migraine Procedure: transcranial direct current stimulation
A constant current of 2 mA intensity applied for 20 min over C3 or C4

Primary Outcome Measures :
  1. Number of participants who experienced pain relief of one level or more [ Time Frame: at 2h post-treatment ]

Information from the National Library of Medicine

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Ages Eligible for Study:   17 Years to 70 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Aged 17-70 years
  • Migraine

    • With or without aura
    • The first attack of migraine was earlier than 50 years of age
    • One to 8 moderate to severe migraine attacks per month in the 2 months preceding the screening
  • Willing and able to give written informed consent
  • Able to read, comprehend and complete the diary form

Exclusion Criteria:

  • Not able to distinguish between migraine and non-migraine headache
  • Combined headache, including the tension type headache and medication overuse headache
  • Pregnant, actively trying to become pregnant or breast-feeding women
  • Uncontrolled and significant medical illness
  • Vertebrobasilar or hemiplegic migraine according to the International Headache Society diagnostic criteria
  • Having intracranial metal implants or a cardiac pacemaker
  • A history of epilepsy or other organic brain disorders
  • A history of psychological diseases
  • Having changed medications for migraine within 1 month before giving us informed consent
  • Drug abuser or alcoholics

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01358279

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Korea, Republic of
Seoul National University Hospital
Seoul, Korea, Republic of, 110-744
Sponsors and Collaborators
Seoul National University Hospital

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Responsible Party: Manho Kim, Manho Kim, MD, PhD Professor, Neurology Seoul National University Hospital, Seoul National University Hospital Identifier: NCT01358279     History of Changes
Other Study ID Numbers: 2009-4615-A
First Posted: May 23, 2011    Key Record Dates
Last Update Posted: October 25, 2016
Last Verified: October 2016

Additional relevant MeSH terms:
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Migraine Disorders
Headache Disorders, Primary
Headache Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases