Value of Von Willebrand Factor in Portal Hypertension
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ClinicalTrials.gov Identifier: NCT01358123
Recruitment Status : Unknown
Verified September 2015 by Arnulf Ferlitsch, MD, Medical University of Vienna. Recruitment status was: Recruiting
First Posted : May 23, 2011
Last Update Posted : September 25, 2015
Medical University of Vienna
Information provided by (Responsible Party):
Arnulf Ferlitsch, MD, Medical University of Vienna
In patients with liver cirrhosis elevated levels of von Willebrand factor antigen (vWF-Ag) are found frequently but the clinical significance is unclear. vWF-Ag plays an important role in primary haemostasis and development of thrombotic vascular obliteration is discussed as a possible mechanism leading to portal hypertension. Invasive measurement of hepatic venous pressure gradient (HVPG) is the current gold standard for the diagnosis of portal hypertension. The investigators hypothesize that vWF-Ag levels in plasma may correlate with portal pressure and predict clinically significant portal hypertension (CSPH, HVPG >=10mmHg) and its complications.
Condition or disease
Liver CirrhosisPortal Hypertension
Patients with alcoholic, viral (chronic hepatitis C), and cryptogenic liver cirrhosis are included. Portal hemodynamics are assessed by HVPG measurement, vWF-Ag levels were measured by ELISA. Results will be compared. 3 and 6 months mortality will be recorded.
von Willebrand Factor Ag Level [ Time Frame: at first visit (HVPG Measurement) (day 1) ]
von Willebrand Factor Antigen Levels are measured via ELISA and compared /corrlated to Hepatic Venous Pressure Gradient (HVPG). von Willebrand Factor Antigen levels are drawn and analyzed at the day of HVPG measurement. No follow up measurements will be performed, survival will be measured as secondary outcome parameter
Secondary Outcome Measures :
Overall Mortality [ Time Frame: 3 Months ]
Survival of Patients after index measurement of von Willebrand Factor and HVPG
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Ages Eligible for Study:
18 Years to 98 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients with liver cirrhosis of all etioloiges, routinely scheduled for routine HVPG measurement will systematically be included during the study period