This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Expanding Rapid Ascertainment Networks of Schizophrenia Families in Taiwan

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2011 by Far Eastern Memorial Hospital.
Recruitment status was:  Recruiting
National Taiwan University Hospital
Information provided by:
Far Eastern Memorial Hospital Identifier:
First received: December 29, 2010
Last updated: May 19, 2011
Last verified: May 2011

This proposal responds to Request for Applications RFA-MH-08-131, which seeks applications that propose to enrich pre-existing resources for schizophrenia in the NIMH Human Genetics Initiative and to apply genomic methods to further our understanding of the molecular etiology of the disorder. The overarching aims of this proposal are to quickly and cost-effectively ascertain a large sample of trio families affected by schizophrenia, and to discover causal variants for the disorder in the first family-based genome-wide association study (GWAS) of the disorder. In Taiwan, there is no such kind of policy to support this kind of GWAS study as it is a very expensive study, including collecting large family samples and genome-wide SNP scanning. The investigators, thus, collaborate with Professor Ming T, Tsuang and his intended subcontracted researchers to apply for this project. The investigators, the research team in Taiwan, will collect 3800 trio families (11400 subjects) of schizophrenia.

The investigators will meet the overarching goals of this project by accomplishing several Specific Aims, as follows: 1) Rapidly ascertain schizophrenia trio families from Taiwanese clinical ascertainment sites; 2) Supplement NIMH Genetics Initiative collections by sending all clinical data and biomaterials to the appropriate repositories; 3) Assess the association of schizophrenia with a genome-wide panel of single-nucleotide polymorphisms (SNPs) and their constituent haplotypes; 4) Analyze quantitative schizophrenia phenotypes such as age at onset ; 5) Perform a genome-wide survey for copy-number variations related to schizophrenia; 6) Test for gene-gene interactions (epistasis); and 7) Test for gene-environment interactions, such as the well-established effect of season of birth.

Condition Intervention
Schizophrenia Other: No intervention would be provided in this research

Study Type: Observational
Study Design: Observational Model: Family-Based
Official Title: Expanding Rapid Ascertainment Networks of Schizophrenia Families in Taiwan

Resource links provided by NLM:

Further study details as provided by Far Eastern Memorial Hospital:

Estimated Enrollment: 300
Study Start Date: October 2010
Estimated Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Schizophrenia Family Other: No intervention would be provided in this research
No intervention would be provided in this research, but need to draw blood


Ages Eligible for Study:   16 Years to 90 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Schizophrenia patients and their biological parents

Inclusion Criteria:

  • clinical diagnosis of schizophrenia and their parents,and parents are still alive

Exclusion Criteria:

  • person with Mental Retardation

    • persons with epilepsy
    • alcohol or substance abuse combined
    • in combination with other organic brain damage syndrome
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01357005

Contact: Hai Gwo Hwu 886-2-23122453 ext 66785

Far Eastern Memorial Hospital Recruiting
Taipei, Taiwan
Contact: Chi Shin Wu         
Sponsors and Collaborators
Far Eastern Memorial Hospital
National Taiwan University Hospital
Study Director: Chi Shin Wu Far Eastern Memorial Hospital
  More Information

Responsible Party: Wu, Chi-Shin/Visiting staff of Psychiatry Department, Far Eastern Memorial Hospital Identifier: NCT01357005     History of Changes
Other Study ID Numbers: 099032-F
Study First Received: December 29, 2010
Last Updated: May 19, 2011

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders processed this record on September 21, 2017