Outcome of Patients Undiagnosed Under Medical Thoracoscopy
Medical thoracoscopy (MT) under local anaesthetic and mild sedation, an established method in the diagnosis of pleural diseases. MT has an overall diagnostic yield above 90% for malignant pleural diseases and pleural tuberculosis. However, others who are diagnosed as fibrinous pleuritis make confusion in clinicians. Whether these patients are firmly followed or not ? The investigators do not know the answer of this question.
In this study the investigators aimed to investigate the outcome of the patients who are diagnosed as fibrinous pleuritis on MT biopsies.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Outcome of Patients Who Could Not Have Been Diagnosed by Medical Thoracoscopy|
- Accuracy of medical thoracoscopy for patients diagnosed as fibrinous pleuritis. [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]During 2 years after medical thoracoscopy, the diagnostic sensitivity, specificity, positive predictive value and negative predictive value are determined in the patients diagnosed as fibrinous pleuritis.
- To determine the factors which point the false positive diagnosis of fibrinous pleuritis. [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]The factors predictive of false-negative biopsy results in the patients with a diagnosis of fibrinous pleuritis are determined by using logistic regression analysis .
|Study Start Date:||February 2002|
|Study Completion Date:||June 2009|
|Primary Completion Date:||May 2009 (Final data collection date for primary outcome measure)|
Patients underwent medical thoracoscopy
Patients who require medical thoracoscopy for undiagnosed exudative pleural effusion by other clinical or radiological investigations.
Procedure: Medical thoracoscopy
Performing medical thoracoscopy to diagnose pleural diseases after cytological and other investigational tests.
Other Name: Rigid thoracoscopy for diagnosis of pleural diseases
Medical thoracoscopy (MT) under local anaesthetic and mild sedation, an established method in the diagnosis of pleural diseases with a sensitivity above 90% and specificity of 1000% for malignant pleural diseases and pleural tuberculosis. Except these two groups of patients, in others pleural histopathological diagnosis is defined as "non-specific pleuritis" or "fibrinous pleuritis". Authors say that the natural evolution of these patients is poorly understood. Some of these patients was later established false negative cases for malignant pleural diseases. Clinical guidelines recommend close observation of patients with undiagnosed exudative effusions, although the length and follow-up regime is not defined, yet. In this study the investigators examine the outcome of patients who are diagnosed as fibrinous pleuritis by MT.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01356979
|ESOGU Medical Faculty Department of Chest Diseases|
|Eskisehir, Meselik - Eskisehir, Turkey, 26040|
|Principal Investigator:||Muzaffer Metintas, MD||ESOGU Medical Faculty Department of Chest Diseases|