The Association Between Different Monocyte Subsets and Coronary Collateral Development

This study has been completed.
Information provided by:
Yuksek Ihtisas Hospital Identifier:
First received: May 17, 2011
Last updated: May 19, 2011
Last verified: March 2011

Collateral growth and coronary angiogenesis are chronic adaptations to myocardial ischemia. Collateralization helps to restore blood flow and as a result salvages myocardium in severely ischemic myocardial regions. Thus, good collateral development in patients with severe coronary artery disease (CAD) improves ventricular function and prognosis (1-3).

However, coronary collateral development is different among patients even with similar degrees of coronary artery stenosis. Several factors, such as diabetes mellitus (4) and duration of myocardial ischemic symptoms (5) have been reported to effect coronary collateral development. At the cellular level, inflammatory cells, especially monocytes have an important role in collateralization. In a series of experimental studies with animals, it has been shown that monocytes are important elements for development of collateral vessels (6-7). In a recent study, it has been demonstrated that increased circulating monocyte count is related to good collateral development in patients with stable coronary artery disease (8).

Monocytes in human blood are heterogeneous and can be classified into two subsets according to the presence or absence of the FcγRIII receptor CD16 (9): CD14++CD16- monocytes characterized by high level expression of the CD14 cell surface receptor but no expression of CD16 receptor, and CD14+CD16+ monocytes characterized by the co-expression of CD16 receptor with either high or low level expression of the CD14 receptor. These subsets differ in function and response to several cytokines.

Our aim in this study was to find out any possible relationship between the levels of circulating monocyte subsets and coronary collateral development.

Coronary Artery Disease
Coronary Ischemia

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Yuksek Ihtisas Hospital:

Enrollment: 105
Study Start Date: January 2011
Study Completion Date: May 2011
Primary Completion Date: May 2011 (Final data collection date for primary outcome measure)
Good-poor collateral
Patients who had good and poor collaterals formed 2 groups
Good collateral, Poor collateral


Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Consecutive patients who were found to have >95% stenosis of at least one major coronary artery in their first coronary angiogram were included in this study.

Inclusion Criteria:

  • > 95% stenosis of at least one major coronary artery in their first coronary angiogram

Exclusion Criteria:

  • previous percutaneous or surgical revascularization history
  • evidence of ongoing infection and inflammation
  • known malignancy and chronic kidney disease (serum creatinine > 1.5 mg/dl
  • diabetic patients
  Contacts and Locations
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Please refer to this study by its identifier: NCT01356836

1Türkiye Yüksek İhtisas Education and Research Hospital, Department of Cardiology
Ankara, Turkey, 06550
Sponsors and Collaborators
Yuksek Ihtisas Hospital
  More Information

No publications provided

Responsible Party: Türkiye Yüksek İhtisas Education and Research Hospital, Specialist of Cardiology Identifier: NCT01356836     History of Changes
Other Study ID Numbers: Monocyte subsets
Study First Received: May 17, 2011
Last Updated: May 19, 2011
Health Authority: Turkey: Turkish Ministry of Health

Keywords provided by Yuksek Ihtisas Hospital:
Coronary collateral development
monocyte subsets

Additional relevant MeSH terms:
Coronary Artery Disease
Coronary Disease
Myocardial Ischemia
Arterial Occlusive Diseases
Cardiovascular Diseases
Heart Diseases
Vascular Diseases processed this record on November 27, 2015