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The Association Between Different Monocyte Subsets and Coronary Collateral Development

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01356836
Recruitment Status : Completed
First Posted : May 20, 2011
Last Update Posted : May 20, 2011
Information provided by:
Yuksek Ihtisas Hospital

Brief Summary:

Collateral growth and coronary angiogenesis are chronic adaptations to myocardial ischemia. Collateralization helps to restore blood flow and as a result salvages myocardium in severely ischemic myocardial regions. Thus, good collateral development in patients with severe coronary artery disease (CAD) improves ventricular function and prognosis (1-3).

However, coronary collateral development is different among patients even with similar degrees of coronary artery stenosis. Several factors, such as diabetes mellitus (4) and duration of myocardial ischemic symptoms (5) have been reported to effect coronary collateral development. At the cellular level, inflammatory cells, especially monocytes have an important role in collateralization. In a series of experimental studies with animals, it has been shown that monocytes are important elements for development of collateral vessels (6-7). In a recent study, it has been demonstrated that increased circulating monocyte count is related to good collateral development in patients with stable coronary artery disease (8).

Monocytes in human blood are heterogeneous and can be classified into two subsets according to the presence or absence of the FcγRIII receptor CD16 (9): CD14++CD16- monocytes characterized by high level expression of the CD14 cell surface receptor but no expression of CD16 receptor, and CD14+CD16+ monocytes characterized by the co-expression of CD16 receptor with either high or low level expression of the CD14 receptor. These subsets differ in function and response to several cytokines.

Our aim in this study was to find out any possible relationship between the levels of circulating monocyte subsets and coronary collateral development.

Condition or disease
Coronary Artery Disease Coronary Ischemia

Study Type : Observational
Actual Enrollment : 105 participants
Observational Model: Cohort
Time Perspective: Prospective
Study Start Date : January 2011
Primary Completion Date : May 2011
Study Completion Date : May 2011

Good-poor collateral
Patients who had good and poor collaterals formed 2 groups
Good collateral, Poor collateral

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Consecutive patients who were found to have >95% stenosis of at least one major coronary artery in their first coronary angiogram were included in this study.

Inclusion Criteria:

  • > 95% stenosis of at least one major coronary artery in their first coronary angiogram

Exclusion Criteria:

  • previous percutaneous or surgical revascularization history
  • evidence of ongoing infection and inflammation
  • known malignancy and chronic kidney disease (serum creatinine > 1.5 mg/dl
  • diabetic patients

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01356836

1Türkiye Yüksek İhtisas Education and Research Hospital, Department of Cardiology
Ankara, Turkey, 06550
Sponsors and Collaborators
Yuksek Ihtisas Hospital

Responsible Party: Türkiye Yüksek İhtisas Education and Research Hospital, Specialist of Cardiology Identifier: NCT01356836     History of Changes
Other Study ID Numbers: Monocyte subsets
First Posted: May 20, 2011    Key Record Dates
Last Update Posted: May 20, 2011
Last Verified: March 2011

Keywords provided by Yuksek Ihtisas Hospital:
Coronary collateral development
monocyte subsets

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases
Pathologic Processes