Comment Period Extended to 3/23/2015 for Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

Effect of Hemodialysis Membranes on Platelet Count

This study has been completed.
Staten Island University Hospital
Information provided by (Responsible Party):
Edward Epstein, North Shore Long Island Jewish Health System Identifier:
First received: May 13, 2011
Last updated: February 6, 2014
Last verified: February 2014

The purpose of this study is to determine if there is a drop in platelet count after hemodialysis. Hemodialysis membranes are known to activate complement and cause a drop in platelets and sometimes in white blood cells. The investigators are going to study one of the membranes which is the Fresenius Optiflux® to check if it causes a drop in platelets.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Effect of Hemodialysis Membranes on Platelet Count

Resource links provided by NLM:

Further study details as provided by North Shore Long Island Jewish Health System:

Primary Outcome Measures:
  • Drop in platelet counts [ Time Frame: 90 minutes through hemodialysis and immediately after finishing hemodialysis ] [ Designated as safety issue: No ]

Enrollment: 99
Study Start Date: September 2010
Study Completion Date: September 2011
Primary Completion Date: September 2011 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients were being selected from the community where undergoing dialysis.


Inclusion Criteria:

  • Patients on Hemodialysis for >=6 months

Exclusion Criteria:

  • Hematological Cancers

    • Myelodysplastic syndromes
    • Baseline thrombocytopenia
    • Acute infections (patients on antibiotics)
    • Patients with Immune thrombocytopenic purpura (ITP)/Thrombotic thrombocytopenic purpura (TTP)
    • HIV
    • Liver disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT01356576

United States, New York
Island Rehabilitative Service
Staten Island, New York, United States, 10305
Sponsors and Collaborators
North Shore Long Island Jewish Health System
Staten Island University Hospital
Principal Investigator: Edwerd Epstein, M.D. Staten Island University Hospital
  More Information

No publications provided

Responsible Party: Edward Epstein, M.D., North Shore Long Island Jewish Health System Identifier: NCT01356576     History of Changes
Other Study ID Numbers: 10-039
Study First Received: May 13, 2011
Last Updated: February 6, 2014
Health Authority: United States: Institutional Review Board processed this record on March 02, 2015