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Effect of Hemodialysis Membranes on Platelet Count

This study has been completed.
Staten Island University Hospital
Information provided by (Responsible Party):
Edward Epstein, North Shore Long Island Jewish Health System Identifier:
First received: May 13, 2011
Last updated: February 6, 2014
Last verified: February 2014
The purpose of this study is to determine if there is a drop in platelet count after hemodialysis. Hemodialysis membranes are known to activate complement and cause a drop in platelets and sometimes in white blood cells. The investigators are going to study one of the membranes which is the Fresenius Optiflux® to check if it causes a drop in platelets.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Effect of Hemodialysis Membranes on Platelet Count

Resource links provided by NLM:

Further study details as provided by Northwell Health:

Primary Outcome Measures:
  • Drop in platelet counts [ Time Frame: 90 minutes through hemodialysis and immediately after finishing hemodialysis ]

Enrollment: 99
Study Start Date: September 2010
Study Completion Date: September 2011
Primary Completion Date: September 2011 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients were being selected from the community where undergoing dialysis.

Inclusion Criteria:

  • Patients on Hemodialysis for >=6 months

Exclusion Criteria:

  • Hematological Cancers

    • Myelodysplastic syndromes
    • Baseline thrombocytopenia
    • Acute infections (patients on antibiotics)
    • Patients with Immune thrombocytopenic purpura (ITP)/Thrombotic thrombocytopenic purpura (TTP)
    • HIV
    • Liver disease
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Please refer to this study by its identifier: NCT01356576

United States, New York
Island Rehabilitative Service
Staten Island, New York, United States, 10305
Sponsors and Collaborators
Northwell Health
Staten Island University Hospital
Principal Investigator: Edwerd Epstein, M.D. Staten Island University Hospital
  More Information

Responsible Party: Edward Epstein, M.D., North Shore Long Island Jewish Health System Identifier: NCT01356576     History of Changes
Other Study ID Numbers: 10-039
Study First Received: May 13, 2011
Last Updated: February 6, 2014

Additional relevant MeSH terms:
Blood Platelet Disorders
Hematologic Diseases processed this record on April 28, 2017