Vascular Fundus Changes in Patients With High Probability of Chronic Cerebrospinal Venous Insufficiency (CCSVI)
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ClinicalTrials.gov Identifier: NCT01356134 |
Recruitment Status :
Completed
First Posted : May 19, 2011
Last Update Posted : April 3, 2015
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Condition or disease |
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Ehlers-Danlos Syndrome Multiple Sclerosis |
Study Type : | Observational |
Actual Enrollment : | 60 participants |
Observational Model: | Case-Control |
Time Perspective: | Cross-Sectional |
Official Title: | Vascular Fundus Changes in Patients With High Probability of CCSVI (Chronic Cerebrospinal Venous Insufficiency) |
Study Start Date : | May 2011 |
Actual Primary Completion Date : | April 2015 |
Actual Study Completion Date : | April 2015 |

Group/Cohort |
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Multiple sclerosis and or Ehlers-Danlos
Patients with suspected or confirmed cases of Ehlers Danlos Syndrome and or Multiple Sclerosis
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Age matched normals
Age matched normals
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- Fundus: venous engorgement/beading [ Time Frame: Baseline ]Abnormal vessel appearance in fundi may include venous engorgement and beading, abnormal A/V ratio, blurred disc margins, papilledema, dot hemorrhages or exudates.

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Ages Eligible for Study: | Child, Adult, Older Adult |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- age matched normals
- patients with diagnosed or suspected Ehlers-Danlos Syndrome and/or diagnosed or suspected Multiple Sclerosis ("CIS")
Exclusion Criteria:
- diabetics and patients unable to sit in position for testing are excluded

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01356134
United States, Texas | |
Total Eye Care | |
Colleyville, Texas, United States, 76034 |
Study Director: | Diana L Driscoll, O.D. | Genetic Disease Investigators | |
Principal Investigator: | Richard A Driscoll, O.D. | Genetic Disease Investigators | |
Study Chair: | Clair A Francomano, M.D. | Harvey Institute for Human Genetics |
Publications:
Responsible Party: | Diana Driscoll, O.D., Principal Investigator, Genetic Disease Investigators |
ClinicalTrials.gov Identifier: | NCT01356134 |
Other Study ID Numbers: |
61/3527 |
First Posted: | May 19, 2011 Key Record Dates |
Last Update Posted: | April 3, 2015 |
Last Verified: | April 2015 |
multiple sclerosis ehlers danlos syndrome CCSVI |
chronic cerebrospinal venous insufficiency fundus retina |
Multiple Sclerosis Venous Insufficiency Ehlers-Danlos Syndrome Sclerosis Pathologic Processes Demyelinating Autoimmune Diseases, CNS Autoimmune Diseases of the Nervous System Nervous System Diseases Demyelinating Diseases Autoimmune Diseases Immune System Diseases Vascular Diseases |
Cardiovascular Diseases Hemostatic Disorders Hemorrhagic Disorders Hematologic Diseases Skin Abnormalities Congenital Abnormalities Skin Diseases, Genetic Genetic Diseases, Inborn Collagen Diseases Connective Tissue Diseases Skin Diseases |