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Heart Rate Changes With Propofol

This study has been completed.
ClinicalTrials.gov Identifier:
First Posted: May 18, 2011
Last Update Posted: May 2, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Christopher Lancaster, Nationwide Children's Hospital
This is a prospective pilot study to quantify the changes in heart rate when propofol is administered after inhalational anesthesia induction.

Condition Intervention
Surgical Patients Other: Observation

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Changes in Heart Rate Following Administration of Propofol After Inhalational Induction

Resource links provided by NLM:

Further study details as provided by Christopher Lancaster, Nationwide Children's Hospital:

Primary Outcome Measures:
  • Change in heart rate [ Time Frame: Baseline & every 30 secs for 3 mins ]

Enrollment: 40
Study Start Date: May 2011
Study Completion Date: May 2012
Primary Completion Date: May 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Propofol Other: Observation
There is no intervention, this is an observational study.


Information from the National Library of Medicine

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Ages Eligible for Study:   1 Year and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Surgery patients at Nationwide Children's Hospital.

Inclusion Criteria:

  1. At least 1 year of age or older.
  2. Routine (elective) surgical patients with ASA classifications of 1 or 2 (healthy).
  3. Patients that are already scheduled to receive inhalational induction followed by IV propofol.

Exclusion Criteria:

1. Premature infants of less than 30 weeks, who are less that 60 weeks post-gestational age at the time of study.

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01355432

United States, Ohio
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Sponsors and Collaborators
Nationwide Children's Hospital
Principal Investigator: Christopher Lancaster, MD Nationwide Children's Hospital
  More Information

Responsible Party: Christopher Lancaster, Attending Anesthesiologist, Nationwide Children's Hospital
ClinicalTrials.gov Identifier: NCT01355432     History of Changes
Other Study ID Numbers: IRB11-00236
First Submitted: May 17, 2011
First Posted: May 18, 2011
Last Update Posted: May 2, 2012
Last Verified: May 2012

Additional relevant MeSH terms:
Hypnotics and Sedatives
Central Nervous System Depressants
Physiological Effects of Drugs
Anesthetics, Intravenous
Anesthetics, General