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Heart Rate Changes With Propofol

This study has been completed.
Information provided by (Responsible Party):
Christopher Lancaster, Nationwide Children's Hospital Identifier:
First received: May 17, 2011
Last updated: May 1, 2012
Last verified: May 2012
This is a prospective pilot study to quantify the changes in heart rate when propofol is administered after inhalational anesthesia induction.

Condition Intervention
Surgical Patients Other: Observation

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Changes in Heart Rate Following Administration of Propofol After Inhalational Induction

Resource links provided by NLM:

Further study details as provided by Christopher Lancaster, Nationwide Children's Hospital:

Primary Outcome Measures:
  • Change in heart rate [ Time Frame: Baseline & every 30 secs for 3 mins ]

Enrollment: 40
Study Start Date: May 2011
Study Completion Date: May 2012
Primary Completion Date: May 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Propofol Other: Observation
There is no intervention, this is an observational study.


Ages Eligible for Study:   1 Year and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Surgery patients at Nationwide Children's Hospital.

Inclusion Criteria:

  1. At least 1 year of age or older.
  2. Routine (elective) surgical patients with ASA classifications of 1 or 2 (healthy).
  3. Patients that are already scheduled to receive inhalational induction followed by IV propofol.

Exclusion Criteria:

1. Premature infants of less than 30 weeks, who are less that 60 weeks post-gestational age at the time of study.

  Contacts and Locations
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Please refer to this study by its identifier: NCT01355432

United States, Ohio
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Sponsors and Collaborators
Nationwide Children's Hospital
Principal Investigator: Christopher Lancaster, MD Nationwide Children's Hospital
  More Information

Responsible Party: Christopher Lancaster, Attending Anesthesiologist, Nationwide Children's Hospital Identifier: NCT01355432     History of Changes
Other Study ID Numbers: IRB11-00236
Study First Received: May 17, 2011
Last Updated: May 1, 2012

Additional relevant MeSH terms:
Hypnotics and Sedatives
Central Nervous System Depressants
Physiological Effects of Drugs
Anesthetics, Intravenous
Anesthetics, General
Anesthetics processed this record on August 23, 2017