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Seed Movement in Prostate Brachytherapy Implants: Clinical Measurement and Dosimetric Consequences

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2014 by AHS Cancer Control Alberta.
Recruitment status was:  Recruiting
Canadian Association of Radiation Oncology
Information provided by (Responsible Party):
AHS Cancer Control Alberta Identifier:
First received: May 16, 2011
Last updated: October 1, 2014
Last verified: October 2014
There are substantial uncertainties with contemporary seed placement techniques in prostate brachytherapy, particularly with the impact of seed movement after an implant due to edema and migration of seeds in the prostate and peri-prostatic tissues. This study will accrue 20 patients undergoing prostate brachytherapy implants and perform serial CT and MRI scans at specified intervals (pre-operatively, day 0, day 3, day 10 and day 28) to characterize these phenomena.

Prostate Cancer

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Seed Movement in Prostate Brachytherapy Implants: Clinical Measurement and Dosimetric Consequences

Resource links provided by NLM:

Further study details as provided by AHS Cancer Control Alberta:

Estimated Enrollment: 20
Study Start Date: August 2011
Estimated Study Completion Date: June 2015
Estimated Primary Completion Date: June 2015 (Final data collection date for primary outcome measure)
Detailed Description:
Prostate brachytherapy is an effective treatment option for men with localized prostate cancer with excellent cure rates and a favorable toxicity profile. Having a more detailed understanding of seed movement after an implant will provide clinicians with details about the clinical impact of these phenomena on implants and provide the detailed understanding of these phenomena that are necessary for more sophisticated brachytherapy implants that are envisioned in the future.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients seen at an academic institution (tertiary centre ...Cross Cancer Institute) for consideration of prostate brachytherapy

Inclusion Criteria:

  • treated with prostate brachytherapy
  • low risk or intermediate risk prostate cancer
  • ambulatory
  • stable medical condition
  • 18 years of age or older
  • capable of informed consent

Exclusion Criteria:

  • no use of any hormonal therapy
  • unable to have MRI scans (ie. presence of metallic foreign object, aneurysm clip, cardiac pacemaker, internal wires, implanted pump, implanted cardiac device, claustrophobia, etc.
  Contacts and Locations
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Please refer to this study by its identifier: NCT01355185

Canada, Alberta
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Sponsors and Collaborators
AHS Cancer Control Alberta
Canadian Association of Radiation Oncology
Principal Investigator: Nawaid Usmani, MD, FRCPC University of Alberta
Principal Investigator: Ronald Sloboda, PhD University of Alberta
  More Information

Responsible Party: AHS Cancer Control Alberta Identifier: NCT01355185     History of Changes
Other Study ID Numbers: 25750 
Study First Received: May 16, 2011
Last Updated: October 1, 2014
Health Authority: Canada: Health Canada

Keywords provided by AHS Cancer Control Alberta:
Seed movement
prostate brachytherapy
localized processed this record on December 07, 2016