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Costimulatory Molecules as Biomarkers in Cystic Fibrosis

This study has been completed.
Information provided by (Responsible Party):
Jeffrey Gold, Oregon Health and Science University Identifier:
First received: May 12, 2011
Last updated: April 4, 2017
Last verified: April 2017
The purpose of this study is to investigate the expression of a certain class of molecules, called costimulatory molecules, in humans with Cystic Fibrosis. Cystic Fibrosis is a genetic disorder which renders the lung susceptible to persistent inflammation which, at times, can worsen, resulting in accelerated decline in lung function and eventually death or transplant. Our goal is to determine if the levels of costimulatory markers can be used to predict exacerbation and subsequent lung function decline in subjects with Cystic Fibrosis.

Cystic Fibrosis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Costimulatory Molecules as Biomarkers in Cystic Fibrosis

Resource links provided by NLM:

Further study details as provided by Oregon Health and Science University:

Biospecimen Retention:   Samples Without DNA
Plasma, Serum, urine

Enrollment: 40
Study Start Date: July 2011
Study Completion Date: June 2013
Primary Completion Date: June 2013 (Final data collection date for primary outcome measure)
Adult Cystic Fibrosis Patients
Adults with Cystic Fibrosis will be followed longitudinally for 2 years


Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Adults with Cystic Fibrosis

Inclusion Criteria:

  • Willingness to participate

Exclusion Criteria:

  • Presence of HIV
  • Presence of Lymphoma/Leukemia
  • Presence of Lung or other solid organ Transplant
  • Pregnancy
  Contacts and Locations
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Please refer to this study by its identifier: NCT01353950

United States, Oregon
Oregon health and Sciences University
Portland, Oregon, United States, 97239
Sponsors and Collaborators
Oregon Health and Science University
  More Information

Responsible Party: Jeffrey Gold, professor, Oregon Health and Science University Identifier: NCT01353950     History of Changes
Other Study ID Numbers: IRB00007132
Study First Received: May 12, 2011
Last Updated: April 4, 2017

Keywords provided by Oregon Health and Science University:
Costimulatory molecules
Cystic Fibrosis

Additional relevant MeSH terms:
Cystic Fibrosis
Pathologic Processes
Pancreatic Diseases
Digestive System Diseases
Lung Diseases
Respiratory Tract Diseases
Genetic Diseases, Inborn
Infant, Newborn, Diseases processed this record on May 23, 2017