Comparison of Nephrotoxicity and Hospital Costs in Patients With Methicillin-Resistant Staphylococcus Aureus Bacteremia Who Received Vancomycin Versus Teicoplanin Therapy
|ClinicalTrials.gov Identifier: NCT01352936|
Recruitment Status : Unknown
Verified May 2011 by Taipei Medical University WanFang Hospital.
Recruitment status was: Active, not recruiting
First Posted : May 12, 2011
Last Update Posted : May 12, 2011
|Condition or disease|
|Staphylococcus Aureus Bacteremia|
In this retrospective observational study, data collection was performed using the patient list extracted from the medical management system of Taipei Medical University-Wan Fang Hospital. Hospitalized patients who had been prescribed either vancomycin or teicoplanin for treating bloodstream infection caused by MRSA and had at least one serum creatinine data within 7 days after initiating glycopeptide therapy were recruited for this study. The major outcome variables of interest were the new onset of nephrotoxicity, which was defined as decrease of glomerular filtration rate (GFR) for more than 25% or 50% from baseline based on serial serum creatinine (SCr) measurements. Other variables including age at admission, gender, comorbidities, laboratory data, concurrent medications (e.g., drug name, dose, route, dosing interval, starting date and end date), and medical cost information were also obtained from the database.
We performed this observational clinical study with 2 main goals: (1) to determine the rate of nephrotoxicity and mortality in patients with MRSA bacteremia treated with vancomycin or teicoplanin; (2) to determine whether vancomycin-associated nephrotoxicity increase length of stay and costs.
|Study Type :||Observational|
|Estimated Enrollment :||190 participants|
|Official Title:||Comparison of Nephrotoxicity and Hospital Costs in Patients With Methicillin-Resistant Staphylococcus Aureus Bacteremia Who Received Vancomycin Versus Teicoplanin Therapy|
|Study Start Date :||January 2011|
|Estimated Study Completion Date :||December 2011|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01352936
|Taipei Medical University - WanFang Hospital|
|Principal Investigator:||Yuh-Mou Sue||Taipei Medical University WanFang Hospital|