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Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2011 by Universitaire Ziekenhuizen Leuven.
Recruitment status was:  Recruiting
Information provided by:
Universitaire Ziekenhuizen Leuven Identifier:
First received: May 11, 2011
Last updated: NA
Last verified: May 2011
History: No changes posted
In this study PEAR1 polymorphisms effects will be analyze in blood platelets to determine how PEAR1 regulates platelet activation.

Condition Intervention
Platelet Function
Other: blood test

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations

Resource links provided by NLM:

Further study details as provided by Universitaire Ziekenhuizen Leuven:

Estimated Enrollment: 100
Study Start Date: May 2011
Estimated Primary Completion Date: May 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: peripheral blood
healthy voluntary donors
Other: blood test
preparation of blood platelets

Detailed Description:
Several large-scale studies have confirmed the long held notion that platelet responses to different agonists are highly variable, within well defined populations of healthy donors. Single nucleotide polymorphisms in genes encoding platelet proteins can explain the wide range of responses to standard platelet agonists. Yet, numerous SNPs point towards proteins with previously unknown function in platelets, wich modulate the complex network of signaling events that regulate platelet function and further augment variability. PEAR1 is mainly expressed in platelets and endothelial cells. A few studies have linked SNPs in PEAR1 with decreased or increased platelet responses to various agonists. However, hitherto, no direct functional studies have been carried out to determine whether and how PEAR1 modulate intracellular signaling pathways relevant for platelet function.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy voluntary donors

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT01352923

Contact: Alexandre Kauskot
Contact: Peter Verhamme

KUleuven/UZ Gasthuisberg Recruiting
Leuven, Vlaams Brabant, Belgium, 3000
Contact: Alexandre Kauskot    +3216346145      
Contact: Marc Houlaerts    +3216346145      
Principal Investigator: Marc Hoylaerts         
Sponsors and Collaborators
Universitaire Ziekenhuizen Leuven
Principal Investigator: Marc Hoylaerts Katholieke Universiteit Leuven
  More Information

Responsible Party: Prof. Marc Hoylaerts, KULeuven Identifier: NCT01352923     History of Changes
Other Study ID Numbers: B322201111373
Study First Received: May 11, 2011
Last Updated: May 11, 2011

Keywords provided by Universitaire Ziekenhuizen Leuven:
PEAR1 gene
whether and how PEAR 1 modulate intracellular signaling pathways relevant for platelet function processed this record on April 26, 2017