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Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2011 by Universitaire Ziekenhuizen Leuven.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01352923
First Posted: May 12, 2011
Last Update Posted: May 12, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Universitaire Ziekenhuizen Leuven
  Purpose
In this study PEAR1 polymorphisms effects will be analyze in blood platelets to determine how PEAR1 regulates platelet activation.

Condition Intervention
Platelet Function Other: blood test

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations

Resource links provided by NLM:


Further study details as provided by Universitaire Ziekenhuizen Leuven:

Estimated Enrollment: 100
Study Start Date: May 2011
Estimated Primary Completion Date: May 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: peripheral blood
healthy voluntary donors
Other: blood test
preparation of blood platelets

Detailed Description:
Several large-scale studies have confirmed the long held notion that platelet responses to different agonists are highly variable, within well defined populations of healthy donors. Single nucleotide polymorphisms in genes encoding platelet proteins can explain the wide range of responses to standard platelet agonists. Yet, numerous SNPs point towards proteins with previously unknown function in platelets, wich modulate the complex network of signaling events that regulate platelet function and further augment variability. PEAR1 is mainly expressed in platelets and endothelial cells. A few studies have linked SNPs in PEAR1 with decreased or increased platelet responses to various agonists. However, hitherto, no direct functional studies have been carried out to determine whether and how PEAR1 modulate intracellular signaling pathways relevant for platelet function.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy voluntary donors

Exclusion Criteria:

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01352923


Contacts
Contact: Alexandre Kauskot alexandre.kauskot@med.kuleuven.be
Contact: Peter Verhamme Peter.Verhamme@uzleuven.be

Locations
Belgium
KUleuven/UZ Gasthuisberg Recruiting
Leuven, Vlaams Brabant, Belgium, 3000
Contact: Alexandre Kauskot    +3216346145      
Contact: Marc Houlaerts    +3216346145      
Principal Investigator: Marc Hoylaerts         
Sponsors and Collaborators
Universitaire Ziekenhuizen Leuven
Investigators
Principal Investigator: Marc Hoylaerts Katholieke Universiteit Leuven
  More Information

Responsible Party: Prof. Marc Hoylaerts, KULeuven
ClinicalTrials.gov Identifier: NCT01352923     History of Changes
Other Study ID Numbers: B322201111373
First Submitted: May 11, 2011
First Posted: May 12, 2011
Last Update Posted: May 12, 2011
Last Verified: May 2011

Keywords provided by Universitaire Ziekenhuizen Leuven:
PEAR1 gene
whether and how PEAR 1 modulate intracellular signaling pathways relevant for platelet function