The Effect of Natural Food Flavourings on Gastrointestinal and Cardiovascular Physiological Responses. (CinnGastEmpt)
Dietary Supplement: Cinnamon
Dietary Supplement: Placebo control
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
|Official Title:||Effect of Cinnamon on Gastric Emptying, Arterial Stiffness, Postprandial Lipaemia, Glycaemia, and Appetite Responses to High-fat Breakfast|
- The effect of 3grams cinnamon on gastric emptying half time [ Time Frame: During the 6.5 hours post ingestion ] [ Designated as safety issue: No ]
- Arterial stiffness [ Time Frame: During the 6.5 hours after ingestion ] [ Designated as safety issue: No ]Post-prandial changes in pulse wave velocity (m/s) will be measured non-invasively, using Pulsetrace PSA2 to indicate arterial stiffness.
- Lipaemia [ Time Frame: During the 6.5 hours after ingestion ] [ Designated as safety issue: No ]Plasma concentration (mmol/l) of triacylglycerols, LDL, and HDL will be measured every hour in the post-prandial period.
- Glycemia [ Time Frame: During the 6.5 hours after ingestion ] [ Designated as safety issue: No ]The concentration of plasma glucose (mmol/l) will measured hourly in the postprandial period, using venous blood drawn from a forearm vein.
- Appetite [ Time Frame: During the 6.5 hours after ingestion ] [ Designated as safety issue: No ]Subjective sensation of hunger, desire to eat, fullness, thirst, tiredness and coldness will be meaured using a 150mm visual analogue scale (mm).
- Oxidative stress [ Time Frame: During the 6.5 hours after ingestion ] [ Designated as safety issue: No ]Serum lipidhydroperoxides will be measured using FOX-1 assay.
- Food intake [ Time Frame: 6 hours post-prandially ] [ Designated as safety issue: No ]A buffet meal will be presented to the volunteer 6h after breakfast. Food intake will be monitored covertly by weighing individiual food items before and after presentation. Food intake will be expressed as macronutrient (carbohydrate, fat, protein, water, fibre) and energy intake.
|Study Start Date:||June 2009|
|Study Completion Date:||March 2010|
|Primary Completion Date:||July 2009 (Final data collection date for primary outcome measure)|
Experimental: Dietary supplementation
3g of cinnamon or placebo control were added to a test-meal.
Dietary Supplement: Cinnamon
acute oral administration of 3 g cinnamonDietary Supplement: Placebo control
3 g wheat flour (placebo)- separated by 28 days from cinnamon intervention
Cinnamon has been shown to delay gastric emptying (GE) of a high-carbohydrate meal and reduce postprandial glycaemia in healthy adults. However, it is dietary fat which is implicated in the etiology and is associated with obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD). We aimed to determine the effect of 3 g cinnamon on GE, postprandial lipemic and glycemic responses, oxidative stress, arterial stiffness, as well as appetite sensations and subsequent food intake following a high-fat (HF) meal.
The effect of acute oral administration of 3 g cinnamon on gastric emptying of a high-fat pancake test meal and subjective appetite sensations by visual analogue scale will be measured for six hours postprandially. During this time course, measurements of postprandial lipemic, glycemic, oxidative stress and arterial stiffness responses will be collected. Subsequently, food intake will be measured using an ad libitum buffet meal. The study will be conducted in a randomized, placebo-controlled, single-blinded manner in 9 healthy subjects.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01350284
|Department of Physical Education & Sport Sciences, University of Limerick|
|Principal Investigator:||Amir Shafat, PhD||Univeristy of Limerick|