The Relationship Between Single Nucleotide Polymorphisms of Chitinase 3-like 1 Gene,YKL-40 Serum Levels and Adult Asthma (CHI3L1)
|ClinicalTrials.gov Identifier: NCT01348932|
Recruitment Status : Unknown
Verified May 2011 by China Medical University Hospital.
Recruitment status was: Recruiting
First Posted : May 6, 2011
Last Update Posted : May 6, 2011
|Condition or disease|
Chitinase 3-like 1 (CHI3L1) is a member of human chitinases family. According to previous studies in literatures, increased expression of CHI3L1 has been proven to be correlated with the presence of different diseases, including cancers, autoimmune diseases, and chronic inflammatory conditions. Elevated serum levels of YKL-40 are associated with increased disease severity, poorer prognosis and shorter survival for many other diseases. When monitored over time, increases in serum YKL-40 parallel with disease progression. It can serve as an measurable marker of changes in disease status.
There were indicated that chitinase 3-like 1 might be associated with some clinical diseases. The C-allele of the -131 C→G (rs4950928) polymorphism of CHI3L1 has been shown to associate with bronchial hyperresponsiveness and reduced lung function. It is suggesting that variations in CHI3L1 may influence risk of asthma.
The objective of this study was to investigate the relationship between single nucleotide polymorphism of chitinase 3-like 1 and human asthma. The association between CHI3L1 SNPs and the continuous outcomes were examined by real time PCR and gene sequencing analysis.
In Korean reports there was no significant associations between CHI3L1 SNPs and asthma were observed. On the other hand, there were association between CHI3L1 and asthma observed in the majority of Caucasian populations. However, similar research has not been conducted in Taiwan. In contrast to preliminary studies, the investigators predict the rs4950928 G allele, and not the C allele, was found to be associated with asthma. The g.-247C/T polymorphism in the CHI3L1 promoter region is associated with the risk of atopy.
|Study Type :||Observational|
|Estimated Enrollment :||1 participants|
|Observational Model:||Case Control|
|Official Title:||The Relationship Between Single Nucleotide Polymorphisms of Chitinase 3-like 1 Gene,YKL-40 Serum Levels and Adult Asthma|
|Study Start Date :||May 2011|
|Estimated Primary Completion Date :||June 2011|
|Estimated Study Completion Date :||December 2013|
The relationship between single nucleotide polymorphisms of chitinase 3-like 1 gene, YKL-40 serum levels and adult asthma
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01348932
|Contact: Chen Chia Hung, firstname.lastname@example.org|
|China Medical University Hospital||Recruiting|
|2 Yuh-Der Road, Taichung, Taiwan, 40447|
|Contact: Chen Chia Hung, doctor 0975680802 email@example.com|
|Study Director:||Chen Chia Hung, doctor||Partners|