Institutional Registry of Amyloidosis
Creating a population-based registry system Amyloidosis prospective epidemiological survey
- risk factors
- Describe the occurrence of amyloidosis in the population of HIBA, Hospital Italiano de Buenos Aires.
- Describe the characteristics of clinical presentation, evolution and predisposing factors of amyloidosis.
|Study Design:||Observational Model: Ecologic or Community
Time Perspective: Prospective
|Official Title:||Institutional Registry of Amyloidosis|
- Epidemiologic characteristics [ Time Frame: From inclusion date to 1year ]
|Study Start Date:||April 2011|
|Estimated Study Completion Date:||January 2020|
|Estimated Primary Completion Date:||January 2020 (Final data collection date for primary outcome measure)|
Amyloidosis is a systemic disease that is usually a result of misfolded proteins in the form of amorphous fibrillar material in various tissues and can cause progressive dysfunction of the same. The prevalence of amyloidosis varies depending on the population concerned and the type of amyloid. While prevalence in the general population is unknown, according to estimates by the Mayo Clinic this prevalence is 1 in 90 666% in the U.S. In England this disease generated about 0.0084% (1367 / 16232579) of all hospital visits between April 2008 and April 2009.
The most common clinical manifestations include cardiac disease, renal and liver function, but it may vary widely depending on the type of amyloidosis, the organ infected and extent of the deposits. Amyloid infiltration can produce signs and symptoms that may be very similar to other rheumatic diseases. This may suggest potential clinical polymorphic underdiagnosis due to low clinical suspicion.
The registries are organized systems of systematic data collection of a large number of patients quickly and efficiently on a particular disease at a given time.
The main difficulty of the registries is the guarantee of the quality of their data.
The main objectives of the registry are:
- Understand risk factors and prognosis.
- Evaluate the diagnostic and therapeutic comparison with current standards.
- Advance knowledge of the disease to optimize the assessment, treatment and monitoring of patients.
- Analyze the effectiveness of new therapies.
- Studying differences between populations.
- Quickly estimate the morbidity, mortality and resource utilization associated with a disease entity.
- Examine the course of a disease
- Formulate novel hypotheses for further prospective studies. Currently, there are registries for patients with transthyretin amyloidosis (TAHOS), global registry of transplant patients with familial amyloid poly neuropathy. Also, there are indirect registries such as the kidney transplant, heart transplant, among others.
The investigators found no data on the prevalence or incidence, evolution and prognosis of amyloidosis in our country. There are no existing records of national Amyloidosis in Latin America that could describe the behavior of this disease in our environment. Because it is a chronic disease with amyloid infiltration and can produce signs and symptoms that may be very similar to other rheumatic diseases, this clinic potentially poliform, may suggest underestimation of low clinical suspicion. As there is no cure, some patients may persist symptomatic despite adequate therapy, that is why it is important the creation of a monitoring system to generate data on the evolution and prognosis. The data registries can be used to develop new treatment guidelines and recommendations, also to inform and educate physicians on the management of this disease.
The Hospital Italiano de Buenos Aires is a center of high complexity of derivation of this type of pathology and due to the fact that the hospital, that has a private health insurance system (HIBA's health plan [plan de salud, PS], gives the unique opportunity denominators for the generation of a population on their affiliates, therefore the investigators propose to make a Institutional Registry of Amyloidosis.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01347047
|Contact: DIego H GIUNTA, MD||+5411 49590200 ext firstname.lastname@example.org|
|Contact: Lourdes Posadas-MArtinez, MD||+5411 49590200 ext email@example.com|
|Hospital Italiano de Buenos Aires||Recruiting|
|Buenos Aires, Argentina|
|Contact: Diego H. Giunta, MD 5411 9590200 ext 4419 firstname.lastname@example.org|
|Study Chair:||María Lourdes Posadas-Martínez, MD||Clinical Research Area Staff|
|Study Chair:||Elsa Nucifora, MD||Hematology Service Chief|
|Study Chair:||Diego Hernan Giunta, MD||Clinical Research Area Coordinator|
|Study Chair:||Dorotea Fantl, MD||Hematology|
|Study Chair:||Gustavo Greloni, MD||Nephrology|
|Study Chair:||Maria Adela Aguirre, MD||Internal Medicine|
|Study Chair:||Cesar Antonio Belziti, MD||Cardiology|
|Study Chair:||Judith Nuñez, Nurse||Hematology Nurse|
|Study Chair:||Melisa M Blomberg, MD||Clinical Research Area Staff|