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The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01346995
First Posted: May 4, 2011
Last Update Posted: May 4, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Frederiksberg University Hospital
  Purpose
The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

Condition Intervention
Muscle Strength Other: Experimental knee pain Other: Non-painful control injections

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

Resource links provided by NLM:


Further study details as provided by Frederiksberg University Hospital:

Primary Outcome Measures:
  • Isokinetic knee muscle strength [ Time Frame: At baseline and after 8 weeks of exercise ]

Secondary Outcome Measures:
  • One-leg chair rise [ Time Frame: At baseline and after 8 weeks of exercise ]

Enrollment: 36
Study Start Date: February 2010
Study Completion Date: August 2010
Primary Completion Date: August 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Experimental Knee Pain
Experimental knee pain induced by injections of 1 ml hypertonic saline in to the infrapatellar fat pad
Other: Experimental knee pain
Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad
Active Comparator: Control
non-painful injections of isotonic saline into the infrapatellar fatpad.
Other: Non-painful control injections
Injection of isotonic saline into the infrapatellar fat pad

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • aged between 20 to 35 years
  • healthy
  • untrained (non-regular exercise participation [i.e. < 1 day/week])

Exclusion Criteria:

  • symptomatic musculoskeletal diseases
  • history of traumatic injuries to muscles, tendons or joints of the lower extremity
  • knee joint pain within a month prior to enrollment
  Contacts and Locations
No Contacts or Locations Provided
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Henning Bliddal, The Parker Institute
ClinicalTrials.gov Identifier: NCT01346995     History of Changes
Other Study ID Numbers: 072.07
First Submitted: May 2, 2011
First Posted: May 4, 2011
Last Update Posted: May 4, 2011
Last Verified: February 2010