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The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

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ClinicalTrials.gov Identifier: NCT01346995
Recruitment Status : Completed
First Posted : May 4, 2011
Last Update Posted : May 4, 2011
Sponsor:
Information provided by:
Frederiksberg University Hospital

Brief Summary:
The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

Condition or disease Intervention/treatment Phase
Muscle Strength Other: Experimental knee pain Other: Non-painful control injections Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 36 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain
Study Start Date : February 2010
Actual Primary Completion Date : August 2010
Actual Study Completion Date : August 2010

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: Experimental Knee Pain
Experimental knee pain induced by injections of 1 ml hypertonic saline in to the infrapatellar fat pad
Other: Experimental knee pain
Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad
Active Comparator: Control
non-painful injections of isotonic saline into the infrapatellar fatpad.
Other: Non-painful control injections
Injection of isotonic saline into the infrapatellar fat pad



Primary Outcome Measures :
  1. Isokinetic knee muscle strength [ Time Frame: At baseline and after 8 weeks of exercise ]

Secondary Outcome Measures :
  1. One-leg chair rise [ Time Frame: At baseline and after 8 weeks of exercise ]


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Ages Eligible for Study:   20 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • aged between 20 to 35 years
  • healthy
  • untrained (non-regular exercise participation [i.e. < 1 day/week])

Exclusion Criteria:

  • symptomatic musculoskeletal diseases
  • history of traumatic injuries to muscles, tendons or joints of the lower extremity
  • knee joint pain within a month prior to enrollment

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Henning Bliddal, The Parker Institute
ClinicalTrials.gov Identifier: NCT01346995     History of Changes
Other Study ID Numbers: 072.07
First Posted: May 4, 2011    Key Record Dates
Last Update Posted: May 4, 2011
Last Verified: February 2010