a 3.0T Magnetic Resonance Imaging Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01346904
Recruitment Status : Unknown
Verified May 2011 by Huazhong University of Science and Technology.
Recruitment status was:  Not yet recruiting
First Posted : May 3, 2011
Last Update Posted : May 3, 2011
Sun Yat-sen University
Information provided by:
Huazhong University of Science and Technology

Brief Summary:
Glaucomatous damage not only occurred to retinal ganglion cells in the eyes, but went across optic nerves, visual chiasm, lateral geniculate nucleus (LGN) and finally the visual cortex; the neural degenerations could be identified through the whole visual tract, which suggests the central nerve system may play a vital role in the progression of glaucoma. The investigators used MRI to investigate changes of visual pathway in vivo.

Condition or disease
Primary Open Angle Glaucoma

Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Central Nerve System Injury in Patients With Primary Open Angle Glaucoma
Study Start Date : May 2011
Estimated Primary Completion Date : December 2012
Estimated Study Completion Date : December 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Glaucoma
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
All subjects recruited from the Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. Clinical ophthalmic assessments including measurement of visual acuities, intraocular pressure, slit-lamp microscopes and funduscopes examinations, cup-to-dick ratio (CDR) evaluation, visual field test [Octopus 101 Automated Perimeter, Haag-streit, Switzerland. Program G2], optical coherence tomography for retinal nerve fiber layer thickness(RNFLT) around the optic disk[Stratus OCT,Carl Zeiss Meditec, Dublin, CA .Scan Type :Fast RNFLT 3.4, Scan Length: 10.87mm].

Inclusion Criteria:

  • Primary open angle glaucoma diagnosed on the basis of glaucomatous optic disc cupping ratio (in particular, thinning of the inferior and/or superior rim, cup-to-disc ratio asymmetry of >0.2)
  • matching glaucomatous visual field defects (European Glaucoma Society (2008) Perimetry )

Exclusion Criteria:

  • optic neuropathy
  • neurological disorder
  • other diseases and use of systemic medications which affect optic nerve or the visual field underwent complete eye examination and visual-field testing.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01346904

Sponsors and Collaborators
Huazhong University of Science and Technology
Sun Yat-sen University
Study Chair: HONG ZHANG, PHD Tongji Hospital

Responsible Party: HONG ZHANG, Department of Opthalmology ,Tongji Hospital Identifier: NCT01346904     History of Changes
Other Study ID Numbers: POAG3243
First Posted: May 3, 2011    Key Record Dates
Last Update Posted: May 3, 2011
Last Verified: May 2011

Additional relevant MeSH terms:
Glaucoma, Open-Angle
Ocular Hypertension
Eye Diseases