Pain Sensitivity in Acute Inflammatory Pain (PASORI)
Pain is a complex experience influenced by gender and genetics, and, by psychosocial and sensory experiences. Pain sensitivity is thus highly variable between individuals.
In the present study we evaluate individuals´ pain perception in response to a number of different pain stimuli in 100 healthy volunteers (50 females and 50 males).
The data will allow us to assess pain sensitivity, to predict pain responses and to investigate gender related differences in pain perception.
A second aim is to evaluate the robustness of the different pain-tests since the tests are repeated with an interval of 2-4 weeks.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Pain Sensitivity in Acute Inflammatory Pain - Gender Differences and Validity of Sensory Tests|
- pain following burn injury [ Time Frame: from baseline to 420 s after burn injury ]
- thermal thresholds [ Time Frame: followed for 180 min after burn injury ]
- tactile thresholds [ Time Frame: followed for 180 min after burn injury ]
- pressure algometry assessments [ Time Frame: 95 min prior to burn injury ]
- DNIC-efficiency [ Time Frame: 45 min before burn injury ]
- cold pressor test [ Time Frame: 85 min before burn injury ]
- HADS score [ Time Frame: 2 hours before the burn injury ]
- PCS ratings [ Time Frame: 2 hours before the burn injury ]
- A118G SNP [ Time Frame: 8 months after inclusion completed ]
|Study Start Date:||February 2010|
|Study Completion Date:||February 2011|
|Primary Completion Date:||July 2010 (Final data collection date for primary outcome measure)|
Procedure: first degree cutaneous burn injury
application of thermode (5 x 2.5 cm) to lower leg temperature 47.0 C, 420 s
Other Name: Modular Sensory Analyzer Thermotest (Somedic, Hörby, Sweden)
Pain perception is affected by physiological, psychological, existential and demographic factors.
In the present study psychophysiological, psychological, genetic and demographic components in pain perception are evaluated in healthy volunteers (n = 100).
Psychophysical assessments following induction of a first degree burn injury (47.0 C, 420 s, 12.5 sq.cm, lower leg) include:
- pain during induction of burn injury
- thermal thresholds
- tactile thresholds
- electrical thresholds
- areas of secondary hyperalgesia
- pressure algometric assessments
- assessment of Diffuse Noxious Inhibitory Control (DNIC) efficiency
- assessment of (DNIC) using cold pressor test
Psychological assessments include:
- HADS (Hospital Anxiety and Depression Scale)
- PCS (Pain Catastrophizing Scale)
- vulnerability score
- A118G SNP
Please refer to this study by its ClinicalTrials.gov identifier: NCT01345877
|Multidisciplinary Pain Center 7612, Neuroscience Center, Rigshospitalet, Blegdamsvej 9|
|Copenhagen O, Denmark, 2100|
|Principal Investigator:||Mads U Werner, MD, DMSc||Multidsciplinary Pain Center 7612, Neuroscience Center, Rigshospitalet, Copenhagen, Denmark|