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The Correlation Between B-type Natriuretic Peptide (BNP) and Global End Diastolic Volume

This study has been completed.
Information provided by (Responsible Party):
Zhongheng Zhang, Jinhua Central Hospital Identifier:
First received: April 27, 2011
Last updated: April 1, 2013
Last verified: September 2012
The investigators hypothesized that the serum B-type Natriuretic Peptide (BNP) level may be correlated with global end diastolic volume (GEDV) as measured by transpulmonary thermodilution technique (PiCCO). The rationale is that some animal studies have proven that BNP is released from ventricular myocardium in response to physical expansion. Such physical expansion can be measured by GEDV. If the hypothesis can be confirmed with our study, the serum level BNP can be used to monitor volume status of critically ill patient, instead of the invasive monitoring system.

Critically Ill

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Correlation Between BNP and Global End Diastolic Volume

Further study details as provided by Jinhua Central Hospital:

Primary Outcome Measures:
  • global end diastolic volume [ Time Frame: within 12 h after measurement of BNP ]
    this is measured by transpulmonary thermodilution technique

Enrollment: 46
Study Start Date: June 2010
Study Completion Date: October 2011
Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
consecutive patients
there is only one group in our study


Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
critically ill patients who required hemodynamic monitoring using PiCCO

Inclusion Criteria:

  • critically ill patients who required hemodynamic monitoring using PiCCO

Exclusion Criteria:

  • patients with renal dysfunction
  • those older than 80 years
  • pregnant women
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Please refer to this study by its identifier: NCT01344265

China, Zhejiang
Jinhua central hospital
Jinhua, Zhejiang, China, 321000
Sponsors and Collaborators
Jinhua Central Hospital
Study Chair: Zhongheng Zhang, MD Jinhua Central Hospital
  More Information

Responsible Party: Zhongheng Zhang, Dr., Jinhua Central Hospital Identifier: NCT01344265     History of Changes
Other Study ID Numbers: zh_zhang1984
Study First Received: April 27, 2011
Last Updated: April 1, 2013

Keywords provided by Jinhua Central Hospital:
B-type natriuretic peptide
global end diastolic volume

Additional relevant MeSH terms:
Critical Illness
Disease Attributes
Pathologic Processes
Natriuretic Peptide, Brain
Natriuretic Agents
Physiological Effects of Drugs processed this record on May 22, 2017