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The Correlation Between B-type Natriuretic Peptide (BNP) and Global End Diastolic Volume

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01344265
First Posted: April 29, 2011
Last Update Posted: April 4, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Zhongheng Zhang, Jinhua Central Hospital
  Purpose
The investigators hypothesized that the serum B-type Natriuretic Peptide (BNP) level may be correlated with global end diastolic volume (GEDV) as measured by transpulmonary thermodilution technique (PiCCO). The rationale is that some animal studies have proven that BNP is released from ventricular myocardium in response to physical expansion. Such physical expansion can be measured by GEDV. If the hypothesis can be confirmed with our study, the serum level BNP can be used to monitor volume status of critically ill patient, instead of the invasive monitoring system.

Condition
Critically Ill

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Correlation Between BNP and Global End Diastolic Volume

Further study details as provided by Zhongheng Zhang, Jinhua Central Hospital:

Primary Outcome Measures:
  • global end diastolic volume [ Time Frame: within 12 h after measurement of BNP ]
    this is measured by transpulmonary thermodilution technique


Enrollment: 46
Study Start Date: June 2010
Study Completion Date: October 2011
Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
consecutive patients
there is only one group in our study

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
critically ill patients who required hemodynamic monitoring using PiCCO
Criteria

Inclusion Criteria:

  • critically ill patients who required hemodynamic monitoring using PiCCO

Exclusion Criteria:

  • patients with renal dysfunction
  • those older than 80 years
  • pregnant women
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01344265


Locations
China, Zhejiang
Jinhua central hospital
Jinhua, Zhejiang, China, 321000
Sponsors and Collaborators
Jinhua Central Hospital
Investigators
Study Chair: Zhongheng Zhang, MD Jinhua Central Hospital
  More Information

Responsible Party: Zhongheng Zhang, Dr., Jinhua Central Hospital
ClinicalTrials.gov Identifier: NCT01344265     History of Changes
Other Study ID Numbers: zh_zhang1984
First Submitted: April 27, 2011
First Posted: April 29, 2011
Last Update Posted: April 4, 2013
Last Verified: September 2012

Keywords provided by Zhongheng Zhang, Jinhua Central Hospital:
B-type natriuretic peptide
global end diastolic volume

Additional relevant MeSH terms:
Critical Illness
Disease Attributes
Pathologic Processes
Natriuretic Peptide, Brain
Natriuretic Agents
Physiological Effects of Drugs