Thrombocytopathy in Gaucher Disease Patients
In Gaucher disease type I bleeding is a common presenting symptom, that may manifest itself as frequent nose bleeds, easy bruising but can also cause substantial bleeding after surgical or dental procedures and may occur in association with pregnancy or delivery . The bleeding tendency is usually considered to be secondary to thrombocytopenia However 50,000 platelets are enough in healthy people to give a normal bleeding time but are associated with significant bleeding tendencies in Gaucher patients. Bleeding tendency might be attributed by genetic inherited or Gaucher related coagulation factors abnormalities which in some cases stabilize with ERT. However, In other cases the etiology is an abnormality of platelet function. This thrombocytopathy has not been delineated and apart from a few aggregation studies, no systematic analysis has been published that convincingly shows the cause of the disturbed function. While, experience shows that enzyme replacement (ERT, i.e: imiglucerase, Cerezyme®) reduces this bleeding tendency, in part due to the improvement in the thrombocyte count and elevation in coagulation factors, it is less clear what effect ERT has on the thrombocytopathy. This has clinical significance when patients need to be prepared for surgery or delivery or in the event of a major bleed. There is no consensus as to how patients should be prepared or treated. Different centres use different approaches. When the procedure is elective ERT is appropriate but in other situations DDAVP, fresh frozen plasma and platelet infusion are possible treatments. Even activated factor VII has been used when bleeding was not controlled. As in any other coagulation abnormality, treatment should be tailored to the specific cause of the bleeding diathesis. The aim of this study is to define the etiology of platelet dysfunction in Gaucher patients.
Hypothesis: The investigators expect to see a difference between platelets activation profile among imiglucerase treated and untreated patients with at least a partial restoration of platelets function due to treatment commencement.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||A 1.5 Years Prospective Study Designed to Delineate the Cause of the Thrombocytopathy in Gaucher Disease Patients|
- Measure thrombocytopathy in a cohort of 70 Gaucher patients using a set of platelet function tests. [ Time Frame: 3 years ]• 70 Gaucher patients managed (treated and untreated controls) will be subjected to a panel of platelets function tests (aggregation test, closure time and FACS analysis).
- Evaluating the impact of Imiglucerase treatment on platelet function [ Time Frame: 3 years ]Platelet function during the 3 years of study will be analyzed versus Imiglucerase treatment status and duration taking into consideration genotype, age at diagnosis, spleen status and Gaucher disease severity at treatment initiation
Biospecimen Retention: Samples Without DNA
|Study Start Date:||October 2010|
|Estimated Study Completion Date:||November 2018|
|Estimated Primary Completion Date:||November 2018 (Final data collection date for primary outcome measure)|
Delineating the cause of the thrombocytopathy in Gaucher disease patients:
- Identifying thrombocytopathy among a cohort of 70 Gaucher patients managed (treated and untreated) in our clinic using a panel of platelets function tests.
- Understanding the etiology for platelets dysfunction in Gaucher disease.
- Evaluating the impact of Imiglucerase treatment duration and Gaucher disease severity on platelet function
Please refer to this study by its ClinicalTrials.gov identifier: NCT01344096
|Contact: Monica Weisz Hubshman, MD||972-3-9377522||MonicaWe@clalit.org.il|
|Contact: Ian J Cohen, Prof.||firstname.lastname@example.org|
|Rambam Medical Center||Not yet recruiting|
|Contact: Hagit Baris, Prof 972-4-7771286 HB_Feldman@rambam.health.gov.il|
|Contact: Ian J Cohen, Prof email@example.com|
|Principal Investigator: Hagit Baris|
|Rabin Medical Center||Recruiting|
|Petach Tikva, Israel, 49100|
|Contact: Monica Weisz Hubshman, MD 972-3-9377522 MonicaWe@clalit.org.il|
|Contact: Ian J Cohen, Prof. firstname.lastname@example.org|
|Principal Investigator: Monica Weisz Hubshman, MD|
|Sub-Investigator: Ian Cohen, Prof.|
|Study Chair:||Ian J Cohen, Prof.||Rabin Medical Center|
|Study Chair:||Hagit Baris, MD||Rambam Health Care Campus|