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Effect of Dairy Fat on Plasma Phytanic Acid in Human

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ClinicalTrials.gov Identifier: NCT01343576
Recruitment Status : Completed
First Posted : April 28, 2011
Last Update Posted : April 28, 2011
Sponsor:
Collaborators:
The Danish Dairy Research Foundation, Denmark
Det Strategiske Forskningsråd
Information provided by:
University of Copenhagen

Brief Summary:
The aim of the study is to investigate if cow feeding regimes affects concentration of plasma phytanic acid and risk markers of the metabolic syndrome in human.

Condition or disease Intervention/treatment
Coronary Heart Disease Dietary Supplement: milk fat

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 14 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: Effect of Dairy Fat on Plasma Phytanic Acid in Healthy Volunteers - A Randomized Controlled Study
Study Start Date : August 2009
Primary Completion Date : November 2009
Study Completion Date : December 2010

Intervention Details:
    Dietary Supplement: milk fat
    45 g milk fat per day in 4 weeks
    Other Names:
    • yellow group
    • Green group


Primary Outcome Measures :
  1. plasma phytanic acid [ Time Frame: before and after the intervention (4 weeks) ]

Secondary Outcome Measures :
  1. total cholesterol [ Time Frame: before and after the intervention (4 weeks) ]
  2. LDL cholesterol [ Time Frame: before and after the intervention (4 weeks) ]
  3. HDL cholesterol [ Time Frame: before and after the intervention (4 weeks) ]
  4. triacylglycerol [ Time Frame: before and after the intervention (4 weeks) ]
  5. C-reactive protein [ Time Frame: before and after the intervention (4 weeks) ]
  6. insulin [ Time Frame: before and after the intervention (4 weeks) ]
  7. glucose [ Time Frame: before and after the intervention (4 weeks) ]
  8. fatty acid composition in plasma [ Time Frame: before and after the intervention (4 weeks) ]


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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • sign written consent
  • Age: 20-42
  • BMI: 20-30
  • increased risk of developing MS
  • refrain from dietary supplements and blood donations prior to, and during the study

Exclusion Criteria:

  • poor compliance
  • if they suffering from any chronic or long lasting illness
  • abuse of alcohol or medicine

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01343576


Locations
Denmark
Department of Human Nutrition
Frederiksberg, Denmark, 1958
Sponsors and Collaborators
University of Copenhagen
The Danish Dairy Research Foundation, Denmark
Det Strategiske Forskningsråd
Investigators
Principal Investigator: Tine Tholstrup, lector Department of Human Nutrition, University of Copenhagen

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Tine Tholstrup, Dpt Human Nutrition, University of Copenhagen, Denmark
ClinicalTrials.gov Identifier: NCT01343576     History of Changes
Other Study ID Numbers: H-B-2009-052 (Adel)
First Posted: April 28, 2011    Key Record Dates
Last Update Posted: April 28, 2011
Last Verified: November 2009

Additional relevant MeSH terms:
Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Cardiovascular Diseases
Vascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases