Biomarkers in Samples From Young Patients With Soft Tissue Sarcoma
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This research trial is studying biomarkers in samples from young patients with soft tissue sarcoma.
Genetic: DNA analysis
Genetic: RNA analysis
Genetic: mutation analysis
Genetic: nucleic acid sequencing
Other: laboratory biomarker analysis
|Study Design:||Observational Model: Case-Only
Time Perspective: Retrospective
|Official Title:||Next Generation Sequencing of Childhood Soft Tissue Sarcomas to Identify Drivers of Primary and Metastatic Disease|
- Occurrence of somatic mutations in driver genes and mutations in other genes that occur individually
|Study Start Date:||May 2011|
|Primary Completion Date:||May 2016 (Final data collection date for primary outcome measure)|
- To identify the key components of driver pathways of primary and secondary soft tissue sarcomas.
- To perform the next-generation sequencing on primary versus normal on undifferentiated sarcomas.
OUTLINE: Genomic DNA and RNA samples from undifferentiated sarcoma tumors are analyzed by next-generation sequencing for somatic mutations. Normal matched lymphocytes and tissue are also analyzed.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01342783
|Principal Investigator:||Poul Sorensen, MD, PhD||British Columbia Cancer Agency|