We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Subclassification of the Syndrome of Inappropriate ADH Secretion

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01341665
First Posted: April 26, 2011
Last Update Posted: April 26, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Wuerzburg
  Purpose

The aim of this study is to evaluate the different types of osmotic dysregulation in patients with Syndrome of Inappropriate ADH (SIADH) and, hence, to analyze the pathophysiology of SIADH.

These types will be characterized by measurement of AVP and copeptin while performing an osmotic stimulation with infusion of hypertonic saline.


Condition
Hyponatremia

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Subclassification of the Syndrome of Inappropriate Antidiuresis Via Copeptin - What is the Genesis of ADH-independent SIADH?

Resource links provided by NLM:


Further study details as provided by University of Wuerzburg:

Estimated Enrollment: 50
Study Start Date: March 2008
Study Completion Date: April 2011
Primary Completion Date: April 2011 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

patients with chronic hyponatremia (> 3 days) due to SIADH in university hospital in wuerzburg

healthy control subjects with normonatremia

Criteria

Inclusion Criteria:

  • age > 18 years,
  • hyponatremia < 132 mmol/L
  • SIADH

Exclusion Criteria:

  • age < 18 years
  • cerebral metastases
  • serum sodium > 132mmol/L
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01341665


Locations
Germany
University of Wuerzburg
Wuerzburg, Bavaria, Germany, 97080
Sponsors and Collaborators
University of Wuerzburg
Investigators
Study Chair: Bruno Allolio, MD Ethical commitee
  More Information

Responsible Party: Prof. Dr. Bruno Allolio, Department of Endocrinology and Diabetes, University of Wuerzburg
ClinicalTrials.gov Identifier: NCT01341665     History of Changes
Other Study ID Numbers: 5/08
First Submitted: April 21, 2011
First Posted: April 26, 2011
Last Update Posted: April 26, 2011
Last Verified: April 2011

Keywords provided by University of Wuerzburg:
hyponatremia
SIADH
copeptin

Additional relevant MeSH terms:
Hyponatremia
Water-Electrolyte Imbalance
Metabolic Diseases