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Subclassification of the Syndrome of Inappropriate ADH Secretion

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ClinicalTrials.gov Identifier: NCT01341665
Recruitment Status : Completed
First Posted : April 26, 2011
Last Update Posted : April 26, 2011
Sponsor:
Information provided by:
University of Wuerzburg

Brief Summary:

The aim of this study is to evaluate the different types of osmotic dysregulation in patients with Syndrome of Inappropriate ADH (SIADH) and, hence, to analyze the pathophysiology of SIADH.

These types will be characterized by measurement of AVP and copeptin while performing an osmotic stimulation with infusion of hypertonic saline.


Condition or disease
Hyponatremia

Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Subclassification of the Syndrome of Inappropriate Antidiuresis Via Copeptin - What is the Genesis of ADH-independent SIADH?
Study Start Date : March 2008
Actual Primary Completion Date : April 2011
Actual Study Completion Date : April 2011

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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

patients with chronic hyponatremia (> 3 days) due to SIADH in university hospital in wuerzburg

healthy control subjects with normonatremia

Criteria

Inclusion Criteria:

  • age > 18 years,
  • hyponatremia < 132 mmol/L
  • SIADH

Exclusion Criteria:

  • age < 18 years
  • cerebral metastases
  • serum sodium > 132mmol/L

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01341665


Locations
Germany
University of Wuerzburg
Wuerzburg, Bavaria, Germany, 97080
Sponsors and Collaborators
University of Wuerzburg
Investigators
Study Chair: Bruno Allolio, MD Ethical commitee

Responsible Party: Prof. Dr. Bruno Allolio, Department of Endocrinology and Diabetes, University of Wuerzburg
ClinicalTrials.gov Identifier: NCT01341665     History of Changes
Other Study ID Numbers: 5/08
First Posted: April 26, 2011    Key Record Dates
Last Update Posted: April 26, 2011
Last Verified: April 2011

Keywords provided by University of Wuerzburg:
hyponatremia
SIADH
copeptin

Additional relevant MeSH terms:
Hyponatremia
Water-Electrolyte Imbalance
Metabolic Diseases