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Finding Early Rheumatoid Arthritis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01341314
Recruitment Status : Unknown
Verified May 2012 by Matthew H. Liang, MD, Brigham and Women's Hospital.
Recruitment status was:  Active, not recruiting
First Posted : April 25, 2011
Last Update Posted : May 24, 2012
Information provided by (Responsible Party):
Matthew H. Liang, MD, Brigham and Women's Hospital

Brief Summary:

Research has shown that early aggressive use of medicines may stop rheumatoid arthritis (RA)or slow its damage. The key to this is to find people with early symptoms which could be RA and have them get a diagnosis, treatment and follow-up.

This study will recruit persons who've gone to the internet looking for information about their symptoms. After answering a screening survey, the person with possible symptoms will be linked to the study website for a more detailed symptom questionnaire.

After completing that questionnaire the person will receive information about the second part of the study which includes an examination with a rheumatologist (arthritis doctor)and laboratory tests.

Based on the joint examination and laboratory tests, the rheumatologist will tell the person the likelihood of having RA, and make recommendations and if needed a referral for care and treatment. Treatment is not a part of this study.

This study will also compare the information on the subject's questionnaires to the doctor's joint examination and the laboratory tests with the hope of developing a simple inexpensive case finding questionnaire.

Condition or disease
Joint Pain Stiffness

Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Proof of Concept of an Internet-based Series Design Case-finding System for Very Early Rheumatoid Arthritis.
Study Start Date : January 2010
Estimated Primary Completion Date : January 2013
Estimated Study Completion Date : July 2013

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Biospecimen Retention:   Samples Without DNA
Frozen serum for future assay development

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
persons with joint pain or swelling for less than 3 months

Inclusion Criteria:

  • Joint pain or swelling for less than 3 months
  • Be able to use the internet

Exclusion Criteria:

  • Non English speaking
  • Diagnosis of rheumatoid arthritis

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01341314

United States, Massachusetts
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Sponsors and Collaborators
Brigham and Women's Hospital

Responsible Party: Matthew H. Liang, MD, Principal Investigator, Brigham and Women's Hospital
ClinicalTrials.gov Identifier: NCT01341314     History of Changes
Other Study ID Numbers: ArthFndtn
First Posted: April 25, 2011    Key Record Dates
Last Update Posted: May 24, 2012
Last Verified: May 2012

Keywords provided by Matthew H. Liang, MD, Brigham and Women's Hospital:
joint pain

Additional relevant MeSH terms:
Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms