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Rebreathing of Carbon Dioxide With a Device Used for Giving Inhalational Anaesthesia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01339013
First Posted: April 20, 2011
Last Update Posted: September 25, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Region Skane
  Purpose
The anesthesia gas reflector (AnaConDa) is built on the adsorptive capacity of active carbon which also adsorbs carbon dioxide in exhaled air. Rebreathing of carbon dioxide thus occurs and must be compensated for by increased ventilation. This study aims at determining how much compensation must be given, based on the hypothesis that rebreathing depends on carbon dioxide level in blood and exhaled air.

Condition Intervention
Anesthetic Ventilatory Requirements Device: Anesthetic Conserving Device (AnaConDa )

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Dead Space Effect of an Anaesthesia Gas Reflector (AnaConDa)

Resource links provided by NLM:


Further study details as provided by Region Skane:

Primary Outcome Measures:
  • Airway Dead Space With Devices for Heat and Moisture Exchange of Respiratory Gas. [ Time Frame: 1 hour ]
    A conventional heat and moisture exchanger used in a respiratory circuit during anasthesia was exchanged by an AnaConDa. The AnaConDa causes re-breathing of carbon dioxide which clinically is equivalent to an increased airway dead space. The total airway dead space effect of the AnaConDa, i.e. volume of the device plus rebreathing from the charcoal filter was measured using the Single Breath Test for carbon dioxide, as was airway deadspace of the conventional Heat and Moisture Exchanger. Airway dead space differences between devices was calculated by subtraction of volumes thus achieved. Difference= Airway dead space AnaConDa - Airway dead space conventional Heat and Moisture Exchanger.


Enrollment: 6
Study Start Date: April 2011
Study Completion Date: January 2013
Primary Completion Date: January 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: AnaConDa Device: Anesthetic Conserving Device (AnaConDa )
Standard HME was replaced by AnaConDa. AnaConDa has charcoal filter, HME does not.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • elective coronary artery by-pass graft surgery
  • elective valve replacement surgery
  • normal left ventricular ejection fraction on preoperative echocardiography

Exclusion Criteria:

  • obstructive lung disease
  • restrictive lung disease
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01339013


Locations
Sweden
University Hospital, Cardiothoracic Intensive Care
Lund, Sweden, SE-221 85
Sponsors and Collaborators
Region Skane
Investigators
Principal Investigator: Mikael Bodelsson, Professor Division of Surgery, Department of Anaesthesia, Skane University Hospital, Lund, Sweden
  More Information

Publications:
Responsible Party: Region Skane
ClinicalTrials.gov Identifier: NCT01339013     History of Changes
Other Study ID Numbers: 20110322
First Submitted: April 13, 2011
First Posted: April 20, 2011
Results First Submitted: March 14, 2014
Results First Posted: September 11, 2014
Last Update Posted: September 25, 2014
Last Verified: September 2014

Keywords provided by Region Skane:
Quantification
ventilatory requirements
charcoal filter

Additional relevant MeSH terms:
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs