A Study of the Inflammatory Pathways Associated With Chronic Obstructive Pulmonary Disease Exacerbations
The purpose of this study is to observe how the inflammatory pathways differ in subjects with chronic obstructive pulmonary disease (COPD) during an acute exacerbation of COPD (AECOPD).
Chronic Obstructive Pulmonary Disease
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||An Exploratory Study of the Cellular Inflammatory Mechanisms Associated With Chronic Obstructive Pulmonary Disease Exacerbations|
- Identification of how inflammatory pathways differ in COPD subjects [ Time Frame: 6 weeks ] [ Designated as safety issue: No ]Identify how inflammatory pathways differ in subjects with COPD during an acute exacerbation relative to when the disease is stable.
- Biomarker Sample Repository [ Time Frame: 6 weeks ] [ Designated as safety issue: No ]Establish a biomarker sample repository to support future target validation for the treatment of subjects with COPD.
Biospecimen Retention: Samples Without DNA
Blood, Endobronchial tissues and Bronchoalveolar (BAL) samples
|Study Start Date:||April 2011|
|Study Completion Date:||February 2012|
|Primary Completion Date:||January 2012 (Final data collection date for primary outcome measure)|
Adult male and female subjects with COPD
This is an observational study in adult male and female subjects with COPD to collect blood, endobronchial tissues and BAL to investigate the inflammatory genes/pathways associated with AECOPD at the time of exacerbation (ie, active disease) and at 6 weeks later (ie, stable disease).
Please refer to this study by its ClinicalTrials.gov identifier: NCT01337661
|Dublin, Ireland, 15|
|Study Director:||Rene van der Merwe, MBChB, MFPM||MedImmune Ltd|
|Principal Investigator:||Prof. Connor Burke||BCF Diagnostics|