Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis
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During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations. Magnesium is a potent vasodilator which may be used to open up the small vessels, in order to reduce organ failure.
Condition or disease
Severe SepsisSeptic Shock
Drug: Magnesium Sulfate
In a single-center open label study we evaluated the effects of magnesium sulphate (MgS) infusion on the sublingual microcirculation perfusion in fluid resuscitated patients with severe sepsis and septic shock within the first 48 hours after ICU admission. Directly prior to and after 1 hour of magnesium sulphate (MgS) infusion (2 gram) systemic hemodynamic variables, sublingual SDF images and standard laboratory tests, were obtained.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
severe sepsis and septic shock after adequate fluid resuscitation according to pulmonary artery catheter measurements
severe sepsis and septic shock
age < 18 years
advanced malignancy or a mean arterial pressure (MAP) < 65 mmHg refractory to vasopressors
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