Trial record 19 of 54 for:
Open Studies | "Organ Transplantation"
Effect of Rapid Transfusion With Fluid Management System (FMS) on Plasma Potassium in Liver Transplantation Recipients
Verified May 2015 by Seoul National University Hospital
Seoul National University
Information provided by (Responsible Party):
Chul-Woo Jung, Seoul National University Hospital
First received: April 5, 2011
Last updated: May 27, 2015
Last verified: May 2015
Rapid infusion of red blood cells is known to result in hyperkalemia in the body. However, potassium concentration in the blood mixture (usually made of RBC, FFP and normal saline) in the reservoir of rapid infusion system and its effect on the plasma potassium change during rapid transfusion are unknown. This study is designed to investigate these changes while massive transfusion is performed during liver transplantation surgery.
Condition Requiring Rapid Transfusion During Liver Transplantation Surgery
||Observational Model: Cohort
Time Perspective: Prospective
||Potassium Change in the Fluid Management System (FMS) Reservoir and Its Effect on the Plasma Potassium Concentration During Liver Transplantation Surgery
Primary Outcome Measures:
- potassium concentration in the Fluid Management System (FMS) reservoir [ Time Frame: after transfusion of 150 ml of blood mixture ] [ Designated as safety issue: No ]
During bolus transfusion (300ml) of blood mixture, blood sample is taken from the side port of infusion line of Fluid Management System (FMS) when 150 ml of blood mixture was transfused. Because the priming volume of the internal circuit is approximately 100 ml, blood sample that was taken after 150 ml transfusion represents the content in the reservoir.
Secondary Outcome Measures:
- plasma potassium of the patient [ Time Frame: before and after transfuison of 300 ml of blood mixture ] [ Designated as safety issue: No ]
Just before transfusion starts, blood samples are taken from the central venous catheter and arterial line at the same time to measure baseline values. At the immediate end of transfusion, blood samples are taken again from the same sites to measure the resultant changes.
| Estimated Enrollment:
| Study Start Date:
| Primary Completion Date:
||March 2015 (Final data collection date for primary outcome measure)
plasma potassium concentrations in the Fluid Management System (FMS) reservoir, arterial blood, and central venous blood
|Ages Eligible for Study:
||19 Years to 80 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
adult liver transplantation recipients
- preoperative anemia (hemoglobin < 10 g/dl)
- preoperative coagulopathy
- children under age 18
- low risk of intraoperative bleeding
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01331889
|Seoul National University Hospital
|Seoul, Korea, Republic of |
|Contact: Chul-Woo Jung, MD. PhD 82-2-2072-2467 firstname.lastname@example.org |
|Sub-Investigator: Ho-Geol Ryu, MD. PhD |
|Sub-Investigator: Jiwon Lee, MD |
Seoul National University Hospital
Seoul National University
||Chul-Woo Jung, MD. PhD
||Seoul National University Hospital
No publications provided
||Chul-Woo Jung, Assistant Professor, Seoul National University Hospital
History of Changes
|Other Study ID Numbers:
|Study First Received:
||April 5, 2011
||May 27, 2015
||Korea: Institutional Review Board
Keywords provided by Seoul National University Hospital:
ClinicalTrials.gov processed this record on July 28, 2015