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Human Circadian Sensitivity to Very Short Light Pulses

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01330992
First Posted: April 7, 2011
Last Update Posted: August 23, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Elizabeth B. Klerman, Brigham and Women's Hospital
  Purpose
The mammalian eye serves both visual and non-image-forming functions. New information about the non-image-forming anatomy and physiology of the eye has revealed effects of ocular light stimuli on human circadian rhythms, melatonin suppression, heart rate, pupillary reflexes, cognitive performance, alertness and sleep. The results of the proposed work can be used to make predictions about the effects of light, to make recommendations involving exposure to or avoidance of light, and to design environmental lighting, resulting in improved health and alertness and decreased errors and accidents.

Condition Intervention
Circadian Rhythm Disorders Other: Ocular light or darkness exposure

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Human Circadian Sensitivity to Very Short Light Pulses

Resource links provided by NLM:


Further study details as provided by Elizabeth B. Klerman, Brigham and Women's Hospital:

Primary Outcome Measures:
  • Circadian Phase (hours) [ Time Frame: Before and after intervention (day 1) ]
    Circadian phase (hours) measured before and after intervention


Estimated Enrollment: 400
Study Start Date: December 2009
Study Completion Date: August 2011
Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Ocular Light or Dark Exposure
Ocular Light or Dark Exposure
Other: Ocular light or darkness exposure
Ocular light or darkness exposure

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy volunteers

Exclusion Criteria:

  • No medications
  • No eye disease
  • No sleep disorders
  • No psychiatric disorders
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01330992


Locations
United States, Massachusetts
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Sponsors and Collaborators
Brigham and Women's Hospital
  More Information

Responsible Party: Elizabeth B. Klerman, Associate Professor, Associate Physician, Brigham and Women's Hospital
ClinicalTrials.gov Identifier: NCT01330992     History of Changes
Other Study ID Numbers: NIH-RC2-HL101340
First Submitted: April 1, 2011
First Posted: April 7, 2011
Last Update Posted: August 23, 2011
Last Verified: August 2011

Keywords provided by Elizabeth B. Klerman, Brigham and Women's Hospital:
Circadian rhythms
Melatonin
Ocular light exposure
Darkness Exposure
Performance
Alertness

Additional relevant MeSH terms:
Chronobiology Disorders
Nervous System Diseases