Microcirculation in Cardiac Surgery (MICROCARD)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01330745
Recruitment Status : Completed
First Posted : April 7, 2011
Last Update Posted : September 8, 2014
Information provided by (Responsible Party):
University Hospital, Rouen

Brief Summary:
The purpose of this study is to determine whether cardiopulmonary bypass affects mesenteric microcirculatory function, using sublingual evaluation, in cardiac surgery.

Condition or disease Intervention/treatment Phase
Cardiac Disorder Other: sublingual microcirculatory evaluation Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 21 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Mesenteric Microcirculatory Function Study Through Sublingual Evaluation During Cardiopulmonary Bypass
Study Start Date : September 2011
Actual Primary Completion Date : March 2014
Actual Study Completion Date : March 2014

Arm Intervention/treatment
aortic valve replacement Other: sublingual microcirculatory evaluation
TNF, ICAM, syndecan-1, heparan sulfate

Primary Outcome Measures :
  1. Microcirculatory impairment [ Time Frame: 36 months ]
    Mean flow index measurement and capillar density study

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • age> 18 years old
  • aortic valvular disease needing aortic valve replacement

Exclusion Criteria:

  • Age<18 years old
  • emergent cardiac surgery
  • other cardiac surgery

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01330745

Rouen University Hospital
Rouen, France, 76031
Sponsors and Collaborators
University Hospital, Rouen
Principal Investigator: Fabien Doguet, MD Rouen University Hospital

Responsible Party: University Hospital, Rouen Identifier: NCT01330745     History of Changes
Other Study ID Numbers: 2009/121/HP
First Posted: April 7, 2011    Key Record Dates
Last Update Posted: September 8, 2014
Last Verified: September 2014

Keywords provided by University Hospital, Rouen:
cardiopulmonary bypass
microcirculatory function

Additional relevant MeSH terms:
Heart Diseases
Cardiovascular Diseases