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Microcirculation in Cardiac Surgery (MICROCARD)

This study has been completed.
Information provided by (Responsible Party):
University Hospital, Rouen Identifier:
First received: April 5, 2011
Last updated: September 5, 2014
Last verified: September 2014
The purpose of this study is to determine whether cardiopulmonary bypass affects mesenteric microcirculatory function, using sublingual evaluation, in cardiac surgery.

Condition Intervention
Cardiac Disorder Other: sublingual microcirculatory evaluation

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Mesenteric Microcirculatory Function Study Through Sublingual Evaluation During Cardiopulmonary Bypass

Further study details as provided by University Hospital, Rouen:

Primary Outcome Measures:
  • Microcirculatory impairment [ Time Frame: 36 months ]
    Mean flow index measurement and capillar density study

Enrollment: 21
Study Start Date: September 2011
Study Completion Date: March 2014
Primary Completion Date: March 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
aortic valve replacement Other: sublingual microcirculatory evaluation
TNF, ICAM, syndecan-1, heparan sulfate


Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • age> 18 years old
  • aortic valvular disease needing aortic valve replacement

Exclusion Criteria:

  • Age<18 years old
  • emergent cardiac surgery
  • other cardiac surgery
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01330745

Rouen University Hospital
Rouen, France, 76031
Sponsors and Collaborators
University Hospital, Rouen
Principal Investigator: Fabien Doguet, MD Rouen University Hospital
  More Information

Responsible Party: University Hospital, Rouen Identifier: NCT01330745     History of Changes
Other Study ID Numbers: 2009/121/HP
Study First Received: April 5, 2011
Last Updated: September 5, 2014

Keywords provided by University Hospital, Rouen:
cardiopulmonary bypass
microcirculatory function

Additional relevant MeSH terms:
Heart Diseases
Cardiovascular Diseases processed this record on September 21, 2017