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Microcirculation in Cardiac Surgery (MICROCARD)

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ClinicalTrials.gov Identifier: NCT01330745
Recruitment Status : Completed
First Posted : April 7, 2011
Last Update Posted : September 8, 2014
Sponsor:
Information provided by (Responsible Party):
University Hospital, Rouen

Brief Summary:
The purpose of this study is to determine whether cardiopulmonary bypass affects mesenteric microcirculatory function, using sublingual evaluation, in cardiac surgery.

Condition or disease Intervention/treatment Phase
Cardiac Disorder Other: sublingual microcirculatory evaluation Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 21 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Mesenteric Microcirculatory Function Study Through Sublingual Evaluation During Cardiopulmonary Bypass
Study Start Date : September 2011
Actual Primary Completion Date : March 2014
Actual Study Completion Date : March 2014

Arm Intervention/treatment
aortic valve replacement Other: sublingual microcirculatory evaluation
TNF, ICAM, syndecan-1, heparan sulfate



Primary Outcome Measures :
  1. Microcirculatory impairment [ Time Frame: 36 months ]
    Mean flow index measurement and capillar density study



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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • age> 18 years old
  • aortic valvular disease needing aortic valve replacement

Exclusion Criteria:

  • Age<18 years old
  • emergent cardiac surgery
  • other cardiac surgery

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01330745


Locations
France
Rouen University Hospital
Rouen, France, 76031
Sponsors and Collaborators
University Hospital, Rouen
Investigators
Principal Investigator: Fabien Doguet, MD Rouen University Hospital

Responsible Party: University Hospital, Rouen
ClinicalTrials.gov Identifier: NCT01330745     History of Changes
Other Study ID Numbers: 2009/121/HP
First Posted: April 7, 2011    Key Record Dates
Last Update Posted: September 8, 2014
Last Verified: September 2014

Keywords provided by University Hospital, Rouen:
cardiopulmonary bypass
mesenteric
microcirculatory function

Additional relevant MeSH terms:
Heart Diseases
Cardiovascular Diseases