Human Papilloma Virus (HPV) Prevalence in the Mouth and Oropharynx of the General Population (Oromouth)
The principal aim of this study is to provide vital current data on the prevalence, distribution and natural history of Human Papilloma Virus (HPV) infection in the mouth. This data is an essential requirement for the assessment, development and evaluation of costeffectiveness of prophylactic vaccination and screening programmes.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||HPV Prevalence in the Mouth and Oropharynx of the General Population|
- Occurrence of HPV in tonsils and in oral scrape sample [ Time Frame: 3 months ] [ Designated as safety issue: No ]
- HPV vaccination status [ Time Frame: 12 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Saliva, Urine, Whole Blood, Mouth brush biopsies (scrapes) and tonsillectomy specimens
|Study Start Date:||August 2011|
|Estimated Study Completion Date:||July 2015|
|Estimated Primary Completion Date:||July 2014 (Final data collection date for primary outcome measure)|
Subjects undergoing tonsillectomy for non-cancer reasons including operations for: recurrent tonsillitis, asymmetric tonsils, snoring surgery or obstructive sleep apnoea.
Patients undergoing a tonsillectomy operation for non-cancerous reasons will be recruited for this study. They will be asked to complete two questionnaires (study and sexual practices), provide saliva, urine and a blood sample. Following anaesthesia, oral mucosal scrappings and a tonsillectomy will be performed and all the samples will be processed for evidence of HPV infection.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01330147
|Contact: Hisham Mehanna, PhD||+44 - firstname.lastname@example.org|
|Contact: Rehan Kazi, PhD||+44 - email@example.com|
|University Hospitals Coventry||Not yet recruiting|
|Coventry, England, United Kingdom, CV2 2DX|
|Principal Investigator: Hisham Mehanna, PhD|
|Sub-Investigator: Rehan Kazi, PhD|
|Principal Investigator:||Hisham Mehanna, FRCS, PhD||University Hospitals Coventry and Warwickshire NHS Trust|