HPV Prevalence in the Mouth and Oropharynx of the Tonsillectomy Population (Oromouth)
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ClinicalTrials.gov Identifier: NCT01330147 |
Recruitment Status
:
Completed
First Posted
: April 6, 2011
Last Update Posted
: May 18, 2017
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Condition or disease |
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Chronic Tonsillitis |
Study Type : | Observational |
Actual Enrollment : | 937 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | HPV Prevalence in the Mouth and Oropharynx of the Tonsillectomy Population |
Study Start Date : | March 2013 |
Actual Primary Completion Date : | September 28, 2015 |
Actual Study Completion Date : | September 28, 2015 |

Group/Cohort |
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Tonsillectomy
Subjects undergoing tonsillectomy for non-cancer reasons including operations for: recurrent tonsillitis, asymmetric tonsils, snoring surgery or obstructive sleep apnoea.
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- Occurrence of HPV in tonsils and in oral scrape sample [ Time Frame: 36 months ]Presence of HPV result
- HPV vaccination status [ Time Frame: 36 months ]vaccination received yes/no and the type of vaccination description
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | up to 65 Years (Child, Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Subjects undergoing tonsillectomy for non cancer reasons including operations for: recurrent tonsillitis, asymmetric tonsils, snoring surgery or obstructive sleep apnoea
- Age - 0 to 65 years
- Subject or legal guardian has given informed written consent
Exclusion Criteria:
- Subjects undergoing adenoidectomy alone with no tonsillectomy
- Subjects with previous oropharyngeal cancer or oral cancer, or any other head and neck cancer such as nasopharyngeal or laryngeal cancer that is currently undergoing or has previously been diagnosed or treated
- Learning disability preventing an adult over 16 years old from giving their own consent

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01330147
United Kingdom | |
University Hospitals Coventry & Warwickshire Trust | |
Coventry, England, United Kingdom, CV2 2DX | |
University Hospital Birmingham | |
Birmingham, West Midlands, United Kingdom, B15 2GW | |
Birmingham City Hospital | |
Birmingham, United Kingdom, B18 7QH | |
Birmingham Children Hospital | |
Birmingham, United Kingdom, B4 6NH | |
Heartlands Hospital | |
Birmingham, United Kingdom, B9 5SS | |
Kidderminster Hospital | |
Kidderminster, United Kingdom, DY11 6RJ | |
New Cross Hospital | |
Wolverhampton, United Kingdom, WV10 0QP | |
Worcestershire Royal Hospital | |
Worcester, United Kingdom, WR5 1DD |
Principal Investigator: | Hisham Mehanna, Prof | The University of Birmingham |
Responsible Party: | University of Birmingham |
ClinicalTrials.gov Identifier: | NCT01330147 History of Changes |
Other Study ID Numbers: |
RG12-208 12344 ( Other Identifier: NIHR ) |
First Posted: | April 6, 2011 Key Record Dates |
Last Update Posted: | May 18, 2017 |
Last Verified: | May 2017 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | Undecided |
Keywords provided by University of Birmingham:
HPV oral cancer oropharyngeal cancer tonsillectomy |
Additional relevant MeSH terms:
Tonsillitis Pharyngitis Pharyngeal Diseases Stomatognathic Diseases |
Respiratory Tract Infections Respiratory Tract Diseases Otorhinolaryngologic Diseases |