Predicting Malignancy Using Endoluminal Ultrasound Characteristics in Mediastinal Lymph Nodes (CT0024)
There is no single method to investigate mediastinal LN invasion. Hence, a patient may have to undergo several tests and procedures. Noninvasive and invasive approaches are employed. Within the invasive techniques, endoscopic ultrasonography with needle aspiration (EUS-FNA) and endobronchial ultrasonography with transbronchial needle aspiration (EBUS-TBNA) are gaining importance in mediastinal staging.5 They provide ultrasonographic images and permit needle aspiration under direct vision for cytology specimen analysis. As more evidence is being accumulated on these staging approaches, the number of cervical mediastinoscopies, considered as the gold-standard for mediastinal staging, is diminishing.
Color Doppler LN characteristics with endoluminal ultrasound (US) is only mentioned in a small number of studies and needs to be further investigated.13,14 With the good results obtained with superficial US, it seems reasonable to believe that color Doppler characteristics would increase accuracy in detecting malignancy of mediastinal LNs with endoluminal US.
Neoplasm of Mediastinal Lymph Nodes
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Predicting Malignancy Using Endoluminal Ultrasound Characteristics in Mediastinal Lymph Nodes|
- With a combination of endoluminal ultrasound characteristics, a simple scoring system can be established to help predict malignancy in mediastinal lymph nodes. [ Time Frame: 3 months ] [ Designated as safety issue: No ]collected characteristics univariate and multivariate logistic regressions will be used to establish a scoring system to predict malignancy. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy will be determined based on the developed model.
|Study Start Date:||June 2011|
|Estimated Study Completion Date:||December 2015|
|Estimated Primary Completion Date:||October 2015 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01329575
|Contact: Vicky Thiffault, RN, CCRP||514-890-8000 ext firstname.lastname@example.org|
|Centre Hospitalier de l'Université de Montréal||Recruiting|
|Montreal, Quebec, Canada, H2L 4M1|
|Contact: Vicky Thiffault, RN, CCRP 514-890-8000 ext 23432 email@example.com|
|Principal Investigator: Moishe Liberman, MD, PhD|
|Sub-Investigator: Pasquale Ferraro, MD|
|Sub-Investigator: André Duranceau, MD|
|Sub-Investigator: Jocelyne Martin, MD|
|Principal Investigator:||Moishe Liberman, MD, PhD||Centre Hospitalier de l'Université de Montréal|