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Late-Life Depression

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2011 by University of Illinois at Chicago.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01327417
First Posted: April 1, 2011
Last Update Posted: April 1, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Institute of Mental Health (NIMH)
Information provided by:
University of Illinois at Chicago
  Purpose
The purpose of the study is to examine the relationship between brain structure and depression in adults aged 60 or older. This relationship is determined using magnetic resonance imaging technology (MRI), a scanner with a magnet that is used to create images of the brain.

Condition
Depression

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Cortical/Subcortical Circuits in Late-Life Depression

Further study details as provided by University of Illinois at Chicago:

Estimated Enrollment: 400
Study Start Date: September 2009
Estimated Study Completion Date: April 2013
Estimated Primary Completion Date: April 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts
Depressed
Patients with Major Depressive Disorder
Healthy Controls

  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
  • Geriatric Medicine and Psychiatry clinics within the UIC Medical Center. Patients with mood and other psychiatric disturbances are frequently referred by physicians from both geriatric medicine and family medicine for a consultation and sometimes for ongoing psychiatric care.
  • Community outreach efforts and recruitment through advertising in newsletters, local newspapers
Criteria

Inclusion Criteria:

  • Age: 60 years or greater
  • Diagnosis of major depressive disorder using standard diagnostic and statistical manual (DSM) criteria
  • Score of 15 or greater on the 17-item Hamilton Depression rating scale
  • Mini Mental Status Exam score of 24 or greater
  • No evidence of clinical dementia or any other clinical brain disorder
  • Free of psychotropic/psychoactive medications for at least 2 weeks

Exclusion Criteria:

  • Presence of dementia or any other clinical brain disorder (Parkinson's, Alzheimer's)
  • History of progressive cognitive decline and/or Mini Mental Status Exam score of less than 24
  • Lifetime diagnosis of substance abuse
  • Unstable medical illness (grade 4 on the Cumulative Illness Rating Scale)
  • Presence of any metallic implant that would preclude an MRI scan (pacemaker, etc.)
  • Concurrent Axis 1 disorder (schizophrenia, bipolar)
  • Psychotropic medication implicated in depression i.e. Reserpine, Alpha methyl dopa, Beta blockers, multiple long acting benzodiazepines (valium, flurazepam, chlordiazepoxide), neuroleptics;
  • Seizure disorder
  • Stroke/Transient Ischemic Attack
  • Central nervous system disorder (Parkinson's disease, multiple sclerosis)
  • Trauma to head/Loss of Consciousness
  • Claustrophobia
  • Eating disorder (anorexia, bulimia)
  • Weight of over 350 pounds
  • Learning disorder (dyslexia, ADHD)
  • Psychosis, panic or anxiety disorder outside the context of depression
  • Mood stabilizing agents such as lithium and Divalproex sodium and antidepressants - as they have been shown to impact on brain levels of NAA, Ch and Ml
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01327417


Contacts
Contact: Piotr Daranowski, MA 312-413-8223 pdaranowski@psych.uic.edu
Contact: Monya Meinel, BA, CCRC 312-996-6201 mmeinel@psych.uic.edu

Locations
United States, Illinois
University of Illinois Recruiting
Chicago, Illinois, United States, 60612
Contact: Monya Meinel, BA, CCRC    312-996-6201    mmeinel@psych.uic.edu   
Sponsors and Collaborators
University of Illinois at Chicago
National Institute of Mental Health (NIMH)
Investigators
Principal Investigator: Anand Kumar, MD University of Illinois at Chicago
  More Information

Additional Information:
Publications:
Responsible Party: Anand Kumar, MD, Head of Psychiatry, University of Illinois
ClinicalTrials.gov Identifier: NCT01327417     History of Changes
Other Study ID Numbers: 2009-0613
R01MH073989 ( U.S. NIH Grant/Contract )
First Submitted: March 30, 2011
First Posted: April 1, 2011
Last Update Posted: April 1, 2011
Last Verified: March 2011

Keywords provided by University of Illinois at Chicago:
Depression

Additional relevant MeSH terms:
Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders