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Late-Life Depression

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ClinicalTrials.gov Identifier: NCT01327417
Recruitment Status : Unknown
Verified March 2011 by University of Illinois at Chicago.
Recruitment status was:  Recruiting
First Posted : April 1, 2011
Last Update Posted : April 1, 2011
Sponsor:
Collaborator:
National Institute of Mental Health (NIMH)
Information provided by:
University of Illinois at Chicago

Brief Summary:
The purpose of the study is to examine the relationship between brain structure and depression in adults aged 60 or older. This relationship is determined using magnetic resonance imaging technology (MRI), a scanner with a magnet that is used to create images of the brain.

Condition or disease
Depression

  Show Detailed Description

Study Type : Observational
Estimated Enrollment : 400 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Cortical/Subcortical Circuits in Late-Life Depression
Study Start Date : September 2009
Estimated Primary Completion Date : April 2013
Estimated Study Completion Date : April 2013

Resource links provided by the National Library of Medicine


Group/Cohort
Depressed
Patients with Major Depressive Disorder
Healthy Controls




Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
  • Geriatric Medicine and Psychiatry clinics within the UIC Medical Center. Patients with mood and other psychiatric disturbances are frequently referred by physicians from both geriatric medicine and family medicine for a consultation and sometimes for ongoing psychiatric care.
  • Community outreach efforts and recruitment through advertising in newsletters, local newspapers
Criteria

Inclusion Criteria:

  • Age: 60 years or greater
  • Diagnosis of major depressive disorder using standard diagnostic and statistical manual (DSM) criteria
  • Score of 15 or greater on the 17-item Hamilton Depression rating scale
  • Mini Mental Status Exam score of 24 or greater
  • No evidence of clinical dementia or any other clinical brain disorder
  • Free of psychotropic/psychoactive medications for at least 2 weeks

Exclusion Criteria:

  • Presence of dementia or any other clinical brain disorder (Parkinson's, Alzheimer's)
  • History of progressive cognitive decline and/or Mini Mental Status Exam score of less than 24
  • Lifetime diagnosis of substance abuse
  • Unstable medical illness (grade 4 on the Cumulative Illness Rating Scale)
  • Presence of any metallic implant that would preclude an MRI scan (pacemaker, etc.)
  • Concurrent Axis 1 disorder (schizophrenia, bipolar)
  • Psychotropic medication implicated in depression i.e. Reserpine, Alpha methyl dopa, Beta blockers, multiple long acting benzodiazepines (valium, flurazepam, chlordiazepoxide), neuroleptics;
  • Seizure disorder
  • Stroke/Transient Ischemic Attack
  • Central nervous system disorder (Parkinson's disease, multiple sclerosis)
  • Trauma to head/Loss of Consciousness
  • Claustrophobia
  • Eating disorder (anorexia, bulimia)
  • Weight of over 350 pounds
  • Learning disorder (dyslexia, ADHD)
  • Psychosis, panic or anxiety disorder outside the context of depression
  • Mood stabilizing agents such as lithium and Divalproex sodium and antidepressants - as they have been shown to impact on brain levels of NAA, Ch and Ml

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01327417


Contacts
Contact: Piotr Daranowski, MA 312-413-8223 pdaranowski@psych.uic.edu
Contact: Monya Meinel, BA, CCRC 312-996-6201 mmeinel@psych.uic.edu

Locations
United States, Illinois
University of Illinois Recruiting
Chicago, Illinois, United States, 60612
Contact: Monya Meinel, BA, CCRC    312-996-6201    mmeinel@psych.uic.edu   
Sponsors and Collaborators
University of Illinois at Chicago
National Institute of Mental Health (NIMH)
Investigators
Principal Investigator: Anand Kumar, MD University of Illinois at Chicago

Additional Information:
Publications of Results:
Other Publications:
Responsible Party: Anand Kumar, MD, Head of Psychiatry, University of Illinois
ClinicalTrials.gov Identifier: NCT01327417     History of Changes
Other Study ID Numbers: 2009-0613
R01MH073989 ( U.S. NIH Grant/Contract )
First Posted: April 1, 2011    Key Record Dates
Last Update Posted: April 1, 2011
Last Verified: March 2011

Keywords provided by University of Illinois at Chicago:
Depression

Additional relevant MeSH terms:
Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders