Frequency and Origin of Dysnatremias in the Emergency Department

This study has been withdrawn prior to enrollment.
(Job change of responsible investigators)
Sponsor:
Collaborator:
Steering committee of the NCCR
Information provided by:
University Hospital Inselspital, Berne
ClinicalTrials.gov Identifier:
NCT01326429
First received: March 29, 2011
Last updated: July 22, 2015
Last verified: July 2015
  Purpose

Hypo- and hypernatremia are the most frequent electrolyte disorders found in hospitalized patients. The increasing use of diuretics and other medications influencing the water and sodium homeostasis potentially lead to a rise in the prevalence of the electrolyte disorders. Only little data is available on the frequency and the mechanisms leading to hypo-/hypernatremia.

Thus, the investigators aim to A.) determine the frequency of hypo- and hypernatremia in the emergency department of a large tertiary university hospital and B.) explore the mechanisms leading to the development of dysnatremias by detailed clinical and laboratory examinations.


Condition
Hyponatremia
Hypernatremia

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Frequency and Origin of Dysnatremias in the Emergency Department

Further study details as provided by University Hospital Inselspital, Berne:

Primary Outcome Measures:
  • Frequency of hypo- and hypernatremia in the emergency department [ Time Frame: approx. 6 months ] [ Designated as safety issue: No ]
    The investigators aim to determine the frequency of hypo- and hypernatremia in the emergency department of a large tertiary university hospital.


Secondary Outcome Measures:
  • Origin of hypo- and hypernatremia in the emergency department [ Time Frame: approx. 6 months ] [ Designated as safety issue: No ]
    The investigators try to investigate the mechanisms leading to the development of hypo- and hypernatremia in patients admitted to the emergency department.


Biospecimen Retention:   Samples With DNA

whole blood


Enrollment: 0
Study Start Date: October 2011
Study Completion Date: March 2013
Primary Completion Date: March 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts
Hypernatremia
Patients admitted to the emergency department with a serum sodium exceeding 145 mmol/L.
Hyponatremia
Patients admitted to the emergency room with a serum sodium below 135 mmol/L.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

All patients admitted to the emergency department of a large tertiary university hospital with a serum sodium below 135 mmol/L (hyponatremia) or exceeding 145 mmol/L.

Criteria

Inclusion Criteria:

  • Serum sodium below 135 mmol/L (i.e. hyponatremia); serum sodium exceeding 145 mmol/L (hypernatremia)

Exclusion Criteria:

  • Patients below age 18 years; patients declining study participation.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01326429

Sponsors and Collaborators
University Hospital Inselspital, Berne
Steering committee of the NCCR
Investigators
Principal Investigator: Gregor Lindner, M.D. Dept. of Nephrology and Hypertension, Inselspital Bern, University of Bern
Study Chair: Felix J Frey, M.D. Dept. of Nephrology and Hypertension, Inselspital Bern, University of Bern
  More Information

Additional Information:
No publications provided

Responsible Party: Gregor Lindner M.D., Dept. of Nephrology and Hypertension, Inselspital Bern, University of Bern
ClinicalTrials.gov Identifier: NCT01326429     History of Changes
Other Study ID Numbers: KEK 019/11
Study First Received: March 29, 2011
Last Updated: July 22, 2015
Health Authority: Switzerland: Ethikkommission

Keywords provided by University Hospital Inselspital, Berne:
Sodium
Hyponatremia
Hypernatremia
Emergency department

Additional relevant MeSH terms:
Emergencies
Hypernatremia
Hyponatremia
Disease Attributes
Metabolic Diseases
Pathologic Processes
Water-Electrolyte Imbalance

ClinicalTrials.gov processed this record on August 26, 2015