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Strategies to Optimize Positive End-expiratory Pressure (PEEP) in Patients With Acute Lung Injury (EIT-PEEP)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2011 by University Hospital, Bonn.
Recruitment status was:  Recruiting
Information provided by:
University Hospital, Bonn Identifier:
First received: July 15, 2010
Last updated: March 29, 2011
Last verified: March 2011
The purpose of this study in patients suffering from acute lung injury is to determine whether positive end-expiratory pressure (PEEP) setting guided by electrical impedance tomography (EIT) influences pulmonary gas exchange, lung mechanics, ventilation/perfusion matching and homogeneity of regional ventilation when compared to other PEEP setting strategies such as the open lung concept or the ARDSnet protocol.

Condition Intervention Phase
Acute Lung Injury
Acute Respiratory Distress Syndrome
Respiratory Failure
Procedure: PEEP titration
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
Official Title: Influence of Different Strategies to Optimize Positive End-expiratory Pressure on Pulmonary Gas Exchange, Perfusion/Ventilation Matching and Homogeneity of Ventilation in Patients With Acute Lung Injury

Resource links provided by NLM:

Further study details as provided by University Hospital, Bonn:

Primary Outcome Measures:
  • homogeneity of regional ventilation delay [ Time Frame: up to eight hours ]
    influence of different PEEP titration strategies on homogeneity of regional ventilation delay measured by electrical impedance tomography

Secondary Outcome Measures:
  • pulmonary gas exchange, lung mechanics and ventilation/perfusion matching [ Time Frame: up to eight hours ]
    influence of different PEEP titration strategies on pulmonary gas exchange, lung mechanics and ventilation/perfusion matching

Estimated Enrollment: 40
Study Start Date: March 2011
Estimated Study Completion Date: June 2013
Estimated Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Acute Lung Injury / ARDS
Patient under mechanical suffering from ALI or ARDS
Procedure: PEEP titration
PEEP is set according to the following protocols, respectively, in a randomized order: ARDSnet table, Open Lung strategy, guided by EIT
Other Name: electrical impedance tomography guided setting of PEEP


Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • acute lung injury, need for optimization of ventilatory settings

Exclusion Criteria:

  • preexisting chronical lung disease, pneumothorax, pace maker, hemodynamical instability, increased intracranial pressure
  Contacts and Locations
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Please refer to this study by its identifier: NCT01326208

University Hospital
Bonn, Germany, 53105
Sponsors and Collaborators
University Hospital, Bonn
Study Chair: Christian Putensen, MD, Prof University of Bonn
Principal Investigator: Thomas Muders, MD University of Bonn
  More Information

Responsible Party: Prof. Dr. Christian Putensen, University of Bonn, Dep. of Anesthesiology and Intensive Care Medicine Identifier: NCT01326208     History of Changes
Other Study ID Numbers: EIT-PEEP-2010 
Study First Received: July 15, 2010
Last Updated: March 29, 2011

Keywords provided by University Hospital, Bonn:
electrical impedance tomography
positive end-expiratory pressure
regional ventilation delay index

Additional relevant MeSH terms:
Wounds and Injuries
Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Adult
Respiratory Insufficiency
Acute Lung Injury
Lung Injury
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Infant, Premature, Diseases
Infant, Newborn, Diseases
Thoracic Injuries processed this record on February 17, 2017